Voltammetric behavior and quantitative determination of ambazone concentrations in urine and in a pharmaceutical formulation

• Authors: Sylwia Smarzewska , Dariusz Guziejewski , Monika Skowron , Slawomira Skrzypek , Witold Ciesielski
• Languages of publication: EN

Abstracts

EN

The use of square wave adsorptive stripping voltammetry (SWAdSV) in conjunction with a cyclic renewable silver amalgam film electrode (Hg(Ag)FE) for the analytical determination of ambazone in urine samples and pharmaceutical formulations is described. A single reduction peak in Britton-Robinson buffer at pH 4.0 was detected at about −1.4 V versus Ag/AgCl. Mechanistic studies have shown that the compound can act as an electrocatalyst. The method was validated. The analytical curve was linear in the concentration range from 1.0×10−9 to 1.0×10−7 mol L−1. The detection and quantification limits were found to be 3.0×10−10 mol L−1 and 1.0×10−9 mol L−1, respectively. The proposed method was successfully applied to ambazone determination in real samples.

Keywords

EN

Voltammetry; Silver amalgam electrode; Ambazone drug analysis; Catalytic hydrogen evolution

• Publisher: De Gruyter Open
• Journal: Open Chemistry
• Year: 2014
• Volume: 12
• Issue: 12
• Pages: 1239-1245

Dates

published

1 - 12 - 2014

online

7 - 6 - 2014

Contributors

author

Sylwia Smarzewska

• University of Lodz

author

Dariusz Guziejewski

• University of Lodz

author

Monika Skowron

• University of Lodz

author

Slawomira Skrzypek

• University of Lodz

author

Witold Ciesielski

• University of Lodz

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Identifiers

DOI

10.2478/s11532-014-0574-7