Preparation of selectively protected protoescigenin derivatives for synthesis of escin analogs and neoglycoconjugates

• Authors: Kamil Jatczak , Mariusz Gruza , Katarzyna Filip , Piotr Cmoch , Grzegorz Grynkiewicz
• Languages of publication: EN

Abstracts

EN

Protoescigenin, the main aglycone of horse chestnut saponin mixture known as escin, was selected as substrate for exploratory chemistry towards selective protection, followed by propargyl ether formation and subsequent condensation with azido-monosaccharides, to obtain novel triazole linked conjugates of the triterpene.

Keywords

EN

Horse chestnut saponins and sapogenins; Protoescigenin derivatization; Click chemistry

• Publisher: De Gruyter Open
• Journal: Open Chemistry
• Year: 2014
• Volume: 12
• Issue: 12
• Pages: 1222-1231

Dates

published

1 - 12 - 2014

online

7 - 6 - 2014

Contributors

author

Kamil Jatczak

• Pharmaceutical Research Institute

author

Mariusz Gruza

• Pharmaceutical Research Institute

author

Katarzyna Filip

• Pharmaceutical Research Institute

author

Piotr Cmoch

author

Grzegorz Grynkiewicz

• Pharmaceutical Research Institute

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Identifiers

DOI

10.2478/s11532-014-0572-9