Ultratrace-level determination of N-Nitrosodimethylamine, N-Nitrosodiethylamine, and N-Nitrosomorpholine in waters by solid-phase extraction followed by liquid chromatography-tandem mass spectrometry

• Authors: Yassine Kadmi , Lidia Favier , Isabelle Soutrel , Marguerite Lemasle , Dominique Wolbert
• Languages of publication: EN

Abstracts

EN

N-nitrosamines are a new class of emerging nitrogenous drinking water disinfection by-products. These compounds are probably carcinogenic which could seriously affect the safety of drinking water consumers. The aim of this study is to develop a simple, fast, and specific analytical method for the routine determination of low part per trillion levels of N-nitrosamines in waters. An ultra high pressure liquid chromatography coupled with tandem mass spectrometry (UHPLC/MS/MS) method was developed for the qualitative and quantitative analysis of N-nitrosamines in waters. N-nitrosamines were extracted, purified and concentrated from water samples in one step using a solid-phase extraction (SPE). The compounds were detected in multiple reaction monitoring via electrospray ionisation source with positive ionisation mode. To achieve symmetrical peak shapes and a short chromatographic analysis time, the mobile phase consisting of acetonitrile, water and formic acid (60:40:0.1, v/v/v) was used in the experiment. Chromatographic separation of N-nitrosamines was done in less than two minutes. All calibration curves had good linearity (r2≥ 0.9989). The intra- and inter-day precision of the assay ranged from 0.59% to 3.11% and accuracy ranged from 99.66% to 104.1%. The mean recoveries of N-nitrosamines in spiked water were 98%-101%. The reproducability was acceptable with relative standard deviations of less than 3.53%. The proposed method yielded detection limits very low which ranges from 0.04 to 0.16 ng L−1. Finally, the developed analytical method was successfully applied to the analysis of N-nitrosamines in natural water sample

Keywords

EN

N-nitrosamines; Disinfection by-products; Ultra high pressure liquid chromatography coupled with tandem mass spectrometry; Solid-phase extraction

• Publisher: De Gruyter Open
• Journal: Open Chemistry
• Year: 2014
• Volume: 12
• Issue: 9
• Pages: 928-936

Dates

published

1 - 9 - 2014

online

1 - 5 - 2014

Contributors

author

Yassine Kadmi

• Université Européenne de Bretagne

author

Lidia Favier

• Université Européenne de Bretagne

author

Isabelle Soutrel

• Université Européenne de Bretagne

author

Marguerite Lemasle

• Université Européenne de Bretagne

author

Dominique Wolbert

• Université Européenne de Bretagne

References

• [1] A. Hebert, D. Forestier, D. Lenes, D. Benanou, S. Jacob, C. Arfi, L. Lambolez, Y. Levi, Water Res. 44, 3147 (2010) http://dx.doi.org/10.1016/j.watres.2010.02.004[Crossref]
• [2] T. Karanfil, W. Krasner Stuart, P. Westerhoff, Y. Xie, J. Am. Chem. Soc. 2 (2008)
• [3] J. Nawrocki, P. Andrzejewski, J. Hazard. Mater. 189, 1(2011) http://dx.doi.org/10.1016/j.jhazmat.2011.02.005[Crossref]
• [4] S. Ventanas, D. Martín, M. Estévez, J. Ruiz, Food Chem. 99, 842 (2006) http://dx.doi.org/10.1016/j.foodchem.2005.08.035[Crossref]
• [5] B. Jurado-Sánchez, E. Ballesteros, M. Gallego, J. Agric. Food Chem. 55, 9758 (2007) http://dx.doi.org/10.1021/jf071437u[Crossref]
• [6] D. M. Pérez, G.G. Alatorre, E.B. Alvarez, E.E. Silva, J.F.J. Alvarado, Food. Chem. 107,1348 (2008) http://dx.doi.org/10.1016/j.foodchem.2007.09.064[Crossref]
• [7] Q. Ma, H.W. Xi, C. Wang, H. Bai, G.C. Xi, N. Su, L.Y. Xu, J.B. Wang, Chin. J. Anal. Chem. 39, 1201 (2011) http://dx.doi.org/10.1016/S1872-2040(10)60466-5[Crossref]
• [8] H.L. Lee, C. Wang, S. Lin, D.P.H. Hsieh, Talanta 73, 6 (2007) http://dx.doi.org/10.1016/j.talanta.2007.03.001[Crossref]
• [9] J.W.A. Charrois, J.M. Boyd, K.L. Froese, S.E. Hrudey, J. Environ. Eng. Sci. 6, 103 (2007) http://dx.doi.org/10.1139/s06-031[Crossref]
• [10] S.D. Richardson, Anal. Chem. 81, 4645 (2009) http://dx.doi.org/10.1021/ac9008012[Crossref]
• [11] M. Krauss, P. Longrée, F. Dorusch, C. Ort, J. Hollender, Water Res. 43, 4381 (2009) http://dx.doi.org/10.1016/j.watres.2009.06.048[Crossref]
• [12] L. Padhye, U. Tezel, W.A. Mitch, S.G. Pavlostathis, C.H. Huang, Environ. Sci. Technol. 43, 3087 (2009) http://dx.doi.org/10.1021/es803067p[Crossref]
• [13] D.L. Sedlak, R.A. Deeb, E.L. Hawley, W.A. Mitch, T.D. Durbin, S. Mowbray, S. Carr, Water Environ. Res. 77, 32 (2005) http://dx.doi.org/10.2175/106143005X41591[Crossref]
• [14] K. Kosaka, K. Fukui, M. Asami, M. Akiba, Water Sci. Technol. 62, 2550 (2010) http://dx.doi.org/10.2166/wst.2010.519[Crossref]
• [15] Y.Y. Zhao, J.M. Boyd, M. Woodbeck, R.C. Andrews, F. Qin, S.E. Hrudey, X.F. Li, Environ. Sci. Technol. 42, 4857 (2008) http://dx.doi.org/10.1021/es7031423[Crossref]
• [16] P. Andrzejewski, B. Kasprzyk-Hordern, J. Nawrocki, Water Res. 42, 863 (2008) http://dx.doi.org/10.1016/j.watres.2007.08.032[Crossref]
• [17] M. Asami, M. Oya, K. Kosaka, Sci. Total Environ. 407, 3540 (2009) http://dx.doi.org/10.1016/j.scitotenv.2009.02.014[Crossref]
• [18] J.M. Boyd, S.E. Hrudey, X.F. Li, S.D. Richardson, TrAC, Trends Anal Chem. 30, 1410 (2011) http://dx.doi.org/10.1016/j.trac.2011.06.009[Crossref]
• [19] I.M. Schreiber, W.A. Mitch, Environ. Sci. Technol. 39, 3811 (2005) http://dx.doi.org/10.1021/es0483286[Crossref]
• [20] United States Environmental Protection Agency (U.S. EPA). Second cycle of the unregulated contaminant monitoring regulation (UCMR2) data summary (US Environmental Protection Agency, USA, 2010)
• [21] Ontario Ministry of the Environment (OME). Technical support document for Ontario drinking water standards, objectives and guidelines (Ontario Ministry of the Environment, Ontario, 2003)
• [22] Public health goal for N-Nitrosodimethylamine in drinking water, (California Department of Public Health (CDPH), USA, 2007) http://www.oehha.ca.gov/
• [23] Guidelines for Drinking-Water Quality, in: N-Nitrosodimethylamine (NDMA), 4th edition (World Health Organization, Geneva, 2011)
• [24] N-nitrosodimethylamine (NDMA) in drinking water, (Federal-Provincial-Territorial Committee on Drinking Water, Health Canada (CDW), Ottawa, Ontario, Canada, 2010)
• [25] C. Planas, Ó. Palacios, F. Ventura, J. Rivera, J. Caixach, Talanta 76, 906 (2008) http://dx.doi.org/10.1016/j.talanta.2008.04.060[Crossref]
• [26] M.C. Huang, H.C. Chen, S.C. Fu, W.H. Ding, Food Chem. 138, 227 (2013) http://dx.doi.org/10.1016/j.foodchem.2012.09.119[Crossref]
• [27] S. Ventanas, J. Ruiz, Talanta 70, 1017 (2006) http://dx.doi.org/10.1016/j.talanta.2006.02.031[Crossref]
• [28] C. Reyes-Contreras, C. Domínguez, J.M. Bayona, J. Chromatogr. A. 1261 (2012)
• [29] A. Llop, F. Borrull, E. Pocurull, Talanta 88, 284 (2012) http://dx.doi.org/10.1016/j.talanta.2011.10.042[Crossref]
• [30] J.A. McDonald, N.B. Harden, L.D. Nghiem, S.J. Khan, Talanta 99, 146 (2012) http://dx.doi.org/10.1016/j.talanta.2012.05.032[Crossref]
• [31] W. Cha, P. Fox, B. Nalinakumari, Anal. Chim. Acta. 566, 109 (2006) http://dx.doi.org/10.1016/j.aca.2006.02.059[Crossref]
• [32] Y.Y. Zhao, J. Boyd, S.E. Hrudey, X.F. Li, Environ. Sci. Technol. 40, 7636 (2006) http://dx.doi.org/10.1021/es061332s[Crossref]
• [33] X. Cheng, H. Shi, C. Adams, T. Timmons, Y. Ma, Global J. Anal. Chem. 2, 232 (2011)
• [34] J.E. Grebel, C.C. Young, I.H. Suffet, J. Chromatogr. A. 1117, 11 (2006) http://dx.doi.org/10.1016/j.chroma.2006.03.044[Crossref]
• [35] H.W. Hung, T.F. Lin, C.H. Chiu, Y.C. Chang, T.Y. Hsieh, Water, Air, Soil Pollut. 213, 459 (2010) http://dx.doi.org/10.1007/s11270-010-0398-9[Crossref]
• [36] B. Jurado-Sánchez, E. Ballesteros, M. Gallego, Talanta 79, 613 (2009) http://dx.doi.org/10.1016/j.talanta.2009.04.035[Crossref]
• [37] J.W. Munch, V. M. Bassett, J. AOAC Int. 89, 486 (2006)
• [38] J.W.A. Charrois, M.W. Arend, K.L. Froese, S.E. Hrudey, Environ. Sci. Technol. 38, 4835 (2004) http://dx.doi.org/10.1021/es049846j[Crossref]

Identifiers

DOI

10.2478/s11532-014-0537-z