Azobenzene functionalized mesoporous AlMCM-41-type support for drug release applications

• Authors: Raul-Augustin Mitran , Daniela Berger , Laura Băjenaru , Silviu Năstase , Cristian Andronescu , Cristian Matei
• Languages of publication: EN

Abstracts

EN

A light-responsive material, aminoazobenzene functionalized AlMCM-41, was synthesized and characterized in order to be used as carrier for drug delivery devices. The light-induced hydrophobic-hydrophilic switching effect of azobenzene functionalized aluminosilicate was exploited in the release of irinotecan, a cytostatic drug. To obtain the functionalized mesoporous support, an azobenzene-silane precursor was synthesized by coupling 4-(4′-aminophenylazo) benzoic acid with 3-aminopropyl triethoxysilane and further grafted on AlMCM-41. The azobenzene functionalized mesoporous aluminosilicate exhibited no significant toxicity towards murine fibroblast healthy cells and a reduced toxicity towards murine melanocyte cells. The hybrid materials obtained by loading irinotecan on AlMCM-41 (wt. 35.4%) and aminoazobenzene modified AlMCM-41 (wt. 22%), respectively were characterized by FTIR, small and wide angle XRD, N2 adsorption-desorption isotherms and DSC analyses. A two-fold increase in the drug release rate from azobenzene functionalized aluminosilicate in phosphate buffer solution under UV irradiation was noticed, as compared with dark conditions. Moreover, the azobenzene functionalization of AlMCM-41 significantly increased the irinotecan delivery rate and total cumulative release in comparison with the pristine AlMCM-41 in similar conditions.

Keywords

EN

Aluminosilicate; Drug delivery systems; Aminoazobenzene; Light-responsive material; Irinotecan

• Publisher: De Gruyter Open
• Journal: Open Chemistry
• Year: 2014
• Volume: 12
• Issue: 7
• Pages: 788-795

Dates

published

1 - 7 - 2014

online

30 - 4 - 2014

Contributors

author

Raul-Augustin Mitran

author

Daniela Berger

• University “Politehnica” of Bucharest

author

Laura Băjenaru

• University “Politehnica” of Bucharest

author

Silviu Năstase

• University “Politehnica” of Bucharest

author

Cristian Andronescu

• Romanian Academy of Sciences

author

Cristian Matei

• University “Politehnica” of Bucharest

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Identifiers

DOI

10.2478/s11532-014-0534-2