Enantioselective Michael additions of aldehydes to nitroalkenes catalyzed with ionically tagged organocatalyst

• Authors: Radovan Šebesta , Attila Latika
• Languages of publication: EN

Abstracts

EN

Enantioselective organocatalytic Michael additions affords useful building blocks for many biologically and medicinally relevant compounds. Ionically-tagged diphenylprolinol silyl ether efficiently catalyzes several Michael additions of aldehydes to nitroalkenes in ionic liquids. The Michael additions work well in ionic liquids; yields up to 95% and enantioselectivities up to 95% ee were achieved. Furthermore, in some cases, the catalytic system was reusable.

Keywords

EN

Organocatalysis; Ionic liquid; Ionic tag; Michael addition; Oseltamivir

• Publisher: De Gruyter Open
• Journal: Open Chemistry
• Year: 2014
• Volume: 12
• Issue: 3
• Pages: 416-425

Dates

published

1 - 3 - 2014

online

21 - 12 - 2013

Contributors

author

Radovan Šebesta

• Comenius University in Bratislava

author

Attila Latika

• Synkola

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Identifiers

DOI

10.2478/s11532-013-0391-4