Spectral properties and photophysical behaviour of water soluble cationic Mg(II) and Al(III) phthalocyanines

• Authors: Mopelola Idowu , Yasin Arslanoğlu , Tebello Nyokong
• Languages of publication: EN

Abstracts

EN

Peripherally and non-peripherally tetrasubstituted-[(N-methyl-2-pyridylthio)]phthalocyaninato magnesium (II) (5 and 6) and chloro aluminium (III) (7 and 8) tetraiodide have been synthesized and characterized. The photophysical properties of the complexes in dimethyl sulfoxide (DMSO) and aqueous medium in the presence and absence of cremophore EL have been studied. These complexes show high solubility in aqueous medium though they were aggregated. The triplet state quantum yields (FT) and the triplet lifetimes (tT) were found to be higher in DMSO with ΦT ranging from 0.32 to 0.51, while tT ranged from 282 to 622 ms in DMSO, compared to aqueous medium (pH 7.4 buffer) where ΦT ranged from 0.15 to 0.19 and tT from 26 to 35 ms. Addition of cremophore EL in aqueous solution resulted in partial disaggregation and increased photoactivity. The fluorescence lifetimes of the complexes showed strong dependence on their immediate environment. The ionic magnesium(II) and aluminium(III) phthalocyanines strongly bind to bovine serum albumin (BSA).

Keywords

EN

Metallophthalocyanine; Water soluble; Aggregation; Photodynamic therapy; Fluorescence lifetime

• Publisher: De Gruyter Open
• Journal: Open Chemistry
• Year: 2014
• Volume: 12
• Issue: 3
• Pages: 403-415

Dates

published

1 - 3 - 2014

online

21 - 12 - 2013

Contributors

author

Mopelola Idowu

author

Yasin Arslanoğlu

author

Tebello Nyokong

• Rhodes University

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Identifiers

DOI

10.2478/s11532-013-0388-z