Polymer conjugates with potential biological activity based on new derivatives of 2-mercaptobenzoxazole-synthesis and characterization

• Authors: Rǎdiţa Aparaschivei , Valeriu Şunel , Mihaela Holban , Marcel Popa , Jacques Desbrieres
• Languages of publication: EN

Abstracts

EN

New potentially biologically active compounds derived from 2-mercapto-benzoxazole were synthesized and coupled on polymeric support of poly (maleic anhydride-alt-vinyl acetate) for the preparation of polymer-drug conjugates with controlled drug release. All compounds were characterized by elemental and spectroscopy (FT-IR, 1H-NMR) analysis. The toxicological tests recommend the products for further laboratory screening. [...]

Keywords

EN

2-mercapto-benzoxazole derivatives; Hydrazides; Drug-polymer conjugates; Poly (maleic anhydride-alt-vinyl acetate)

• Publisher: De Gruyter Open
• Journal: Open Chemistry
• Year: 2013
• Volume: 11
• Issue: 11
• Pages: 1808-1815

Dates

published

1 - 11 - 2013

online

25 - 8 - 2013

Contributors

author

Rǎdiţa Aparaschivei

author

Valeriu Şunel

• Department of Organic Chemistry, Faculty of Chemistry, “Al.I.Cuza” University, 700506, Iasi, Romania

author

Mihaela Holban

• Department of Organic Chemistry, Faculty of Chemistry, “Al.I.Cuza” University, 700506, Iasi, Romania

author

Marcel Popa

• Department of Natural and Synthetic Polymers, Faculty of Chemical Engineering and Environmental Protection, “Gheorghe Asachi” Technical University of Iasi, 700050, Iasi, Romania

author

Jacques Desbrieres

• IPREM, Helioparc Pau Pyrenees, Pau and Adour Countries University (UPPA), 64053, PAU cedex 9, France

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Identifiers

DOI

10.2478/s11532-013-0310-8