Determination of some frequently used antibiotics in waste waters using solid phase extraction followed by high performance liquid chromatography with diode array and mass spectrometry detection

• Authors: Ocsana Opriş , Maria-Loredana Soran , Virginia Coman , Florina Copaciu , Dumitru Ristoiu
• Languages of publication: EN

Abstracts

EN

This study is focused on the determination of some important antibiotics from different classes in waste water samples using solid phase extraction followed by high performance liquid chromatography with two detectors, diode array and mass spectrometer in positive ionisation mode. The investigated antibiotics include three penicillins (amoxicillin, ampicillin, penicillin G), two cephalosporins (ceftazidime, ceftriaxone), and two tetracyclines (tetracycline, doxycycline). The studied antibiotics were extracted from waste water samples using hydrophilic-lipophilic balanced cartridges. The extraction of antibiotics from water matrices was tested at several pH values. The best recoveries were obtained at pH 3 and 7 respectively. Depending on the nature of antibiotic, the limits of detection and quantification were obtained in the range of 0.07–0.92 µg mL−1 and 0.21–2.77 µg mL−1 respectively. Influent and effluent waste water samples were collected from a Waste Water Treatment Plant from Romania in order to detect the studied antibiotics. The antibiotics detected in the influent waste water samples were ceftriaxone (334 µg L−1), tetracycline (146 µg L−1) and doxycycline (110 µg L−1). In effluent waste water samples no target antibiotics were detected. [...]

Keywords

EN

Antibiotics; Waste waters; Solid-phase extraction; High performance liquid chromatography; Mass spectrometry

• Publisher: De Gruyter Open
• Journal: Open Chemistry
• Year: 2013
• Volume: 11
• Issue: 8
• Pages: 1343-1351

Dates

published

1 - 8 - 2013

online

1 - 6 - 2013

Contributors

author

Ocsana Opriş

• National Institute for Research and Development of Isotopic and Molecular Technologies, Cluj-Napoca, 400293, Romania

author

Maria-Loredana Soran

• National Institute for Research and Development of Isotopic and Molecular Technologies, Cluj-Napoca, 400293, Romania

author

Virginia Coman

• “Raluca Ripan“ Institute for Research in Chemistry, Babeş-Bolyai University, Cluj-Napoca, 400294, Romania

author

Florina Copaciu

• “Raluca Ripan“ Institute for Research in Chemistry, Babeş-Bolyai University, Cluj-Napoca, 400294, Romania

author

Dumitru Ristoiu

• Faculty of Environmental Sciences and Engineering, Babeş-Bolyai University, Cluj-Napoca, 400294, Romania

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Identifiers

DOI

10.2478/s11532-013-0263-y