The first synthesis of 3-deoxyoripavine and its utilization in the preparation of 10-deoxyaporphines and cyprodime

• Authors: Attila Sipos , Antal Udvardy , Attila Bényei , Sándor Berényi
• Languages of publication: EN

Abstracts

EN

The synthesis of 3-deoxyoripavine (7) was realized as a novel and promising intermediate towards the synthesis of the important class of dopaminergic and/or serotonergic 10-deoxyaporphines and the special pharmacological tool µ opioid antagonist cyprodime. Generally, the preparation of these valuable biologically active compounds was achieved in remarkable yields. [...]

Keywords

EN

Oripavine; Cyprodime; 10-deoxyaporphines; Reduction; Acid-catalyzed rearrangement

• Publisher: De Gruyter Open
• Journal: Open Chemistry
• Year: 2013
• Volume: 11
• Issue: 8
• Pages: 1278-1285

Dates

published

1 - 8 - 2013

online

1 - 6 - 2013

Contributors

author

Attila Sipos

• Department of Pharmaceutical Chemistry, Medical and Health Science Centre, University of Debrecen, H-4010, Debrecen, Hungary

author

Antal Udvardy

• Department of Physical Chemistry, University of Debrecen, H-4010, Debrecen, Hungary

author

Attila Bényei

author

Sándor Berényi

• Department of Organic Chemistry, University of Debrecen, H-4010, Debrecen, Hungary

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Identifiers

DOI

10.2478/s11532-013-0256-x