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Journal

2013 | 11 | 6 | 927-934

Article title

A TLC Study of the lipophilicity of thirty-two acetylcholinesterase inhibitors - 1,2,3,4-tetrahydroacridine and 2,3-dihydro-1H-cyclopenta[b]quinoline derivatives

Content

Title variants

Languages of publication

EN

Abstracts

EN
The lipophilicity of thirty-two novel acetylcholinesterase (AChE) inhibitors - 1,2,3,4-tetrahydroacridine and 2,3-dihydro-1H-cyclopenta[b]quinoline derivatives was studied by thin layer chromatography. The analyzed compounds were chromatographed on RP-18, RP-8, RP-2, CN and NH2 stationary phases with dioxane - citric buffer pH 3.0 binary mobile phases containing different proportions of dioxane. RM values for pure water were extrapolated from the linear Soczewiński-Wachtmeister equation and six compounds with known literature log P values were used as reference calibration data set for computation of experimental log P values. [...] The obtained results were compared with computationally calculated partition coefficients values (AlogPs, AClogP, AlogP, MlogP, KOWWIN, XlogP2, XlogP3) by PCA and significant differences between them were observed.

Publisher

Journal

Year

Volume

11

Issue

6

Pages

927-934

Physical description

Dates

published
1 - 6 - 2013
online
28 - 3 - 2013

Contributors

  • Department of Pharmaceutical Chemistry and Drug Analyses, Medical University, 90-151, Łódź, Poland
  • Department of Medicinal Chemistry, Faculty of Pharmacy, Medical University of Lublin, 20-090, Lublin, Poland
  • Department of Medicinal Chemistry, Faculty of Pharmacy, Medical University of Lublin, 20-090, Lublin, Poland
  • Department of Medicinal Chemistry, Faculty of Pharmacy, Medical University of Lublin, 20-090, Lublin, Poland
  • Department of Pharmaceutical Chemistry and Drug Analyses, Medical University, 90-151, Łódź, Poland
  • Department of Medicinal Chemistry, Faculty of Pharmacy, Medical University of Lublin, 20-090, Lublin, Poland

References

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Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.-psjd-doi-10_2478_s11532-013-0218-3
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