Full-text resources of PSJD and other databases are now available in the new Library of Science.
Visit https://bibliotekanauki.pl

PL EN


Preferences help
enabled [disable] Abstract
Number of results

Journal

2013 | 11 | 4 | 619-628

Article title

Solubilisation of camptothecin by nonionic surfactants and alkyldimethylamine oxides

Content

Title variants

Languages of publication

EN

Abstracts

EN
The solubilisation of poorly soluble antineoplastic drug camptothecin by nonionic surfactants (polysorbates and octylphenol ethoxylates) and alkyldimethylamine oxide surfactants with the alkyl chain length 8 to 16 carbon atoms was investigated. The hydrophobicity of the solubilising agent turned out to be the primary structural parameter controlling the solubility efficiency of camptothecin in an aqueous solution. The quantitative parameter of solubilisation (drug loading coefficient) provided values in the range of 0.1–1.2% and 0.1–1.0% for alkyldimethylamine oxides and nonionic surfactants, respectively. The decreasing number of oxyethylene units and the extension of the hydrophobic part of nonionic surfactant molecule resulted in the increase of camptothecin solubility. From the dynamic light scattering measurements, the hydrodynamic diameter values of camptothecin-loaded alkyldimethylamine oxide and nonionic micelles were found in the range of 4–42 nm and 5–120 nm, respectively. The experimental values confirmed the increase in micellar size with the increasing alkyl chain length. The values of the packing parameter of camptothecin-loaded dodecyldimethylamine oxide micelles indicate their spherical shape at all the investigated surfactant concentrations. A simple computer model of camptothecin-loaded dodecyldimethylamine oxide micelle provided the diameter of the structure cross section which is consistent with the experimental values. [...]

Publisher

Journal

Year

Volume

11

Issue

4

Pages

619-628

Physical description

Dates

published
1 - 4 - 2013
online
23 - 1 - 2013

Contributors

  • Department of Chemical Theory of Drugs, Faculty of Pharmacy, Comenius University, SK-83232, Bratislava, Slovakia
  • Department of Chemical Theory of Drugs, Faculty of Pharmacy, Comenius University, SK-83232, Bratislava, Slovakia
  • Department of Chemical Theory of Drugs, Faculty of Pharmacy, Comenius University, SK-83232, Bratislava, Slovakia

References

  • [1] L. Li, Y.B. Tan, J. Colloid Interface Sci. 317, 326 (2008) http://dx.doi.org/10.1016/j.jcis.2007.09.053[Crossref]
  • [2] R.R. Sawant, R.M. Sawant, V.P. Torchilin, Eur. J. Pharm. Biopharm. 70, 51 (2008) http://dx.doi.org/10.1016/j.ejpb.2008.04.016[Crossref]
  • [3] R. Barreiro-Iglesias, L. Bromberg, M. Temchenko, T.A. Hatton, A. Concheiro, C. Alvarez-Lorenzo, J. Control. Release 97, 537 (2004) http://dx.doi.org/10.1016/j.jconrel.2004.04.007[Crossref]
  • [4] J. Wang, R. Wang, L. Li, J. Colloid Interface Sci. 336, 808 (2009) http://dx.doi.org/10.1016/j.jcis.2009.04.080[Crossref]
  • [5] Y. Gao, L. Li, G. Zhai, Colloids Surf. B 64, 194 (2008) http://dx.doi.org/10.1016/j.colsurfb.2008.01.021[Crossref]
  • [6] W. Zhang, J. Huang, N. Fan, J. Yu, Y. Liu, S. Liu, D. Wang, Y. Li, Colloids Surf. B 81, 297 (2008) http://dx.doi.org/10.1016/j.colsurfb.2010.07.019[Crossref]
  • [7] P. Opanasopit, M. Yokoyama, M. Watanabe, K. Kawano, Y. Maitani, T. Okano, J. Control. Release 104, 313 (2005) http://dx.doi.org/10.1016/j.jconrel.2005.02.014[Crossref]
  • [8] M. Watanabe, K. Kawano, M. Yokoyama, P. Opanasopit, T. Okano, Y. Maitani, Int. J. Pharm. 308, 183 (2006) http://dx.doi.org/10.1016/j.ijpharm.2005.10.030[Crossref]
  • [9] K. Kawano, M. Watanabe, T. Yamamoto, M. Yokoyama, P. Opanasopit, T. Okano, Y. Maitani, J. Control. Release 112, 329 (2006) http://dx.doi.org/10.1016/j.jconrel.2006.03.012[Crossref]
  • [10] J. Gao, J. Ming, B. He, Y. Fan, Z. Gu, X. Zhang, Eur. J. Pharm. Sci. 34, 85
  • [11] B. Shi, C. Fang, M.X. You, Y. Zhang, S. Fu, Y. Pei, Colloid Polym. Sci. 283, 954 (2005) http://dx.doi.org/10.1007/s00396-004-1243-8[Crossref]
  • [12] Y. Chang, I. Chu, Eur. Polym. J. 44, 3922 (2008) http://dx.doi.org/10.1016/j.eurpolymj.2008.09.021[Crossref]
  • [13] O. M. Koo, I. Rubinstein, H. Onyuksel, Nanomed. Nanotech. Biol. Med. 1, 77 (2005) http://dx.doi.org/10.1016/j.nano.2004.11.002[Crossref]
  • [14] J. Kang, V. Kumar, D. Yang, P.R. Chowdhury, R.J. Hohl, Eur. J. Pharm. Sci. 15, 163 (2002) http://dx.doi.org/10.1016/S0928-0987(01)00214-7[Crossref]
  • [15] A. M. Sætern, N.B. Nguyen, A. Bauer-Brandl, M. Brandl, Int. J. Pharm. 284, 61 (2004) http://dx.doi.org/10.1016/j.ijpharm.2004.07.014[Crossref]
  • [16] Y. Jiang, X. Sha, W. Zhang, X. Fang, Int. J. Pharm. 397, 116 (2010) http://dx.doi.org/10.1016/j.ijpharm.2010.07.012[Crossref]
  • [17] Y. Çirpanli, E. Bilensoy, A.L. Dogan, S. Çalis, Eur. J. Pharm. Biopharm. 73, 82 (2009) http://dx.doi.org/10.1016/j.ejpb.2009.04.013[Crossref]
  • [18] Y. Çirpanli, E. Allard, C. Passirani, E. Bilensoy, L. Lemaire, S. Çalis, J. Benoit, Int. J. Pharm. 403, 201 (2011) http://dx.doi.org/10.1016/j.ijpharm.2010.10.015[Crossref]
  • [19] S. Swaminathan, L. Pastero, L. Serpe, F. Trotta, P. Vavia, D. Aquilano, M. Trotta, G. Zara, R. Cavalli, Eur. J. Pharm. Biopharm. 74, 193 (2010) http://dx.doi.org/10.1016/j.ejpb.2009.11.003[Crossref]
  • [20] T. A. Jó, D.F.S. Petri, L.M. Beltramini, N. Lucyszyn, M.R. Sierakowski, Carbohydr. Polym. 82, 355 (2010) http://dx.doi.org/10.1016/j.carbpol.2010.04.072[Crossref]
  • [21] M. Han, C. He, Q. Fang, X. Yang, Y. Diao, D. Xu, Q. He, Y. Hu, W. Liang, B. Yang, J. Gao, Pharm. Res. 26, 926 (2009) http://dx.doi.org/10.1007/s11095-008-9795-9[Crossref]
  • [22] Y. Cheng, M. Li, T. Xu, Eur. J. Med. Chem. 43, 1791 (2008) http://dx.doi.org/10.1016/j.ejmech.2007.09.030[Crossref]
  • [23] K. M. Tyner, S.R. Schiffman, E.P. Giannelis, J. Control. Release 95, 501 (2004) http://dx.doi.org/10.1016/j.jconrel.2003.12.027[Crossref]
  • [24] P. Botella, I. Abasolo, Y. Fernández, C. Muniesa, S. Miranda, M. Quesada, J. Ruiz, S. Schwartz Jr., A. Corma, J. Control. Release 156, 246 (2011) http://dx.doi.org/10.1016/j.jconrel.2011.06.039[Crossref]
  • [25] H. Zhang, C.P. Hollis, Q. Zhang, T. Li, Int. J. Pharm. 415, 293 (2011) http://dx.doi.org/10.1016/j.ijpharm.2011.05.075[Crossref]
  • [26] J. Liu, L. Li, Eur. J. Pharm. Sci. 25, 237 (2005) http://dx.doi.org/10.1016/j.ejps.2005.02.013[Crossref]
  • [27] J. Liu, L. Li, Y. Cai, Eur. Polym. J. 42, 1767 (2006) http://dx.doi.org/10.1016/j.eurpolymj.2006.03.005[Crossref]
  • [28] J. Liu, L. Li, J. Biomed. Mater. Res. Part A 83A, 1103 (2007) http://dx.doi.org/10.1002/jbm.a.31445[Crossref]
  • [29] F. Devínsky, I. Lacko, A. Nagy, L. Krasnec, Chem. Papers 32, 106 (1978)
  • [30] J.E. Desnoyers, G. Caron, R. DeLisi, D. Roberts, A. Roux, G. Perron J Phys Chem 87, 1397 (1983) http://dx.doi.org/10.1021/j100231a024[Crossref]
  • [31] H.J.Y. El-Aila, J. Surf. Det. 8, 165 (2005) http://dx.doi.org/10.1007/s11743-005-342-6[Crossref]
  • [32] L. Brinchi, L. Germani, P. Di Profio, L. Marte, R. Oda, D. Berti, J. Colloid Interface Sci. 346, 100 (2010) http://dx.doi.org/10.1016/j.jcis.2010.02.035[Crossref]
  • [33] S.K. Hait, S.P. Moulik, J. Surf. Det. 4, 303 (2001) http://dx.doi.org/10.1007/s11743-001-0184-2[Crossref]
  • [34] S.W. Provencher, Comput. Phys. Commun. 27, 229 (1982) http://dx.doi.org/10.1016/0010-4655(82)90174-6[Crossref]
  • [35] Sybyl 8.0., Molecular Modeling Software packages (Tripos mc., St.Louis MO, USA, 2007)
  • [36] H. Liang, Q. Yang, L. Deng, J. Lu, J. Chen, Drug Dev. Ind. Pharm. 37, 597 (2011) http://dx.doi.org/10.3109/03639045.2010.533276[Crossref]
  • [37] M.J. Rosen, Surfactants, Interfacial Phenomena, 3rd edition (Wiley, New York, 2004) 108 http://dx.doi.org/10.1002/0471670561[Crossref]
  • [38] C. Tanford, J. Phys. Chem. 76, 3020 (1972) http://dx.doi.org/10.1021/j100665a018[Crossref]
  • [39] V. Garamus, K. Kameyama, R. Kadehashi, Colloid Polym. Sci. 277, 868 (1999) http://dx.doi.org/10.1007/s003960050463[Crossref]
  • [40] H. Maeda, S. Muroi, R. Kakehashi, J. Phys. Chem. B 101, 7378 (1997) http://dx.doi.org/10.1021/jp9633815[Crossref]
  • [41] M.L. Connolly, Science 221, 709 (1983) http://dx.doi.org/10.1126/science.6879170[Crossref]

Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.-psjd-doi-10_2478_s11532-012-0199-7
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.