Pulse perturbation technique for determination of piroxicam in pharmaceuticals using an oscillatory reaction system

• Authors: Nataša Pejić , Nataša Sarap , Jelena Maksimović , Slobodan Anić , Ljiljana Kolar-Anić
• Languages of publication: EN

Abstracts

EN

A simple and reliable novel kinetic method for the determination of piroxicam (PX) was proposed and validated. For quantitative determination of PX, the Bray-Liebhafsky (BL) oscillatory reaction was used in a stable non-equilibrium stationary state close to the bifurcation point. Under the optimized reaction conditions (T = 55.0°C, [H2SO4]0 = 7.60×10−2 mol L−1, [KIO3]0 = 5.90×10−2 mol L−1, [H2O2]0 = 1.50×10−1 mol L−1 and j 0 = 2.95×10−2 min−1), the linear relationship between maximal potential shift ΔE m , and PX concentration was obtained in the concentration range 11.2–480.5 µg mL−1 with a detection limit of 9.9 µg mL−1. The method had a rather good sample throughput of 25 samples h−1 with a precision RSD = 4.7% as well as recoveries RCV ≤ 104.4%. Applicability of the proposed method to the direct determination of piroxicam in different pharmaceutical formulations (tablets, ampoules and gel) was demonstrated. [...]

Keywords

EN

Piroxicam; Perturbation technique; Bray-Liebhafsky oscillatory reaction; Pharmaceutical preparations

• Publisher: De Gruyter Open
• Journal: Open Chemistry
• Year: 2013
• Volume: 11
• Issue: 2
• Pages: 180-188

Dates

published

1 - 2 - 2013

online

29 - 11 - 2012

Contributors

author

Nataša Pejić

• Faculty of Pharmacy, Department of Physical Chemistry and the Instrumental Methods, University of Belgrade, 11000, Belgrade, Serbia

author

Nataša Sarap

• Institute of Nuclear Science Vinča, Radiation and Environmental Protection Department, University of Belgrade, 11001, Belgrade, Serbia

author

Jelena Maksimović

• Faculty of Physical Chemistry, University of Belgrade, 11000, Belgrade, Serbia

author

Slobodan Anić

• Faculty of Physical Chemistry, University of Belgrade, 11000, Belgrade, Serbia

author

Ljiljana Kolar-Anić

• Faculty of Physical Chemistry, University of Belgrade, 11000, Belgrade, Serbia

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Identifiers

DOI

10.2478/s11532-012-0146-7