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Journal

2012 | 10 | 5 | 1534-1546

Article title

Pattern recognition methods as supplementary techniques for identification of salicylamide - cyclodextrins inclusion complexes

Content

Title variants

Languages of publication

EN

Abstracts

EN
The objective of this study was to learn whether or not the pattern recognition methods, such as agglomerative cluster analysis (CA) and principal component analysis (PCA), can be used as supplementary techniques for identification of salicylamide (SAA) inclusion complexes with β-cyclodextrin (β-CD) and 2-hydroxypropyl-β-cyclodextrin (HP-β-CD). To do this, phase-solubility of SAA in the presence of the cyclodextrins was studied by the Higuchi-Connors method, which showed that the cyclodextrins enhanced the solubility of SAA in water as compared to that of the drug. Next, the solid phase complexes of the drug with β-CD and HP-β-CD were prepared by using the coprecipitation, precipitation-evaporation, and kneading methods. Identification of the inclusion complexes was performed by using thermal analysis, infrared spectroscopy, and wide angle X-ray scattering. Two multivariate statistical methods, CA and PCA, were used as the supplementary techniques for identification of the inclusion complexes. The results of the statistical analysis have shown that CA and PCA are helpful for interpretation of the thermoanalytical and spectral data. Moreover, these methods enabled proper classification of the products in all doubtful cases. They can be used as supplementary techniques to verify the conclusions of the above-mentioned standard methods. [...]

Publisher

Journal

Year

Volume

10

Issue

5

Pages

1534-1546

Physical description

Dates

published
1 - 10 - 2012
online
21 - 7 - 2012

Contributors

  • Department of Analytical Chemistry, Medical University of Gdansk, 80-416, Gdansk, Poland
  • Department of Analytical Chemistry, Medical University of Gdansk, 80-416, Gdansk, Poland
  • Institute of Chemical Technology and Engineering, Poznan University of Technology, 60-695, Poznan, Poland

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Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.-psjd-doi-10_2478_s11532-012-0067-5
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