Effect of selenium in organic and inorganic form on liver, kidney, brain and muscle of Wistar rats

• Authors: Jiri Sochor , Miroslav Pohanka , Branislav Ruttkay-Nedecky , Ondrej Zitka , David Hynek , Petr Mares , Ladislav Zeman , Vojtech Adam , Rene Kizek
• Languages of publication: EN

Abstracts

EN

Selenium is a micronutrient, localized in the active sites of enzymes such as glutathione peroxidase and thioredoxin reductase, and participating together with these enzymes in an antioxidant defence system of organisms against free radicals. Administration of selenium is necessary for maintaining oxidative homeostasis. The present experiment is aimed at investigation of selenium impact on basal metabolic processes and selected antioxidants in a Wistar rat model, fed selenium in organic and inorganic forms. Liver, kidney, brain and muscle were sampled during a month-long feeding with four different doses of selenium (0.075 mg or 1.5 mg of inorganic and/or organic selenium per kg of feed). We found a significant reduction in glutathione level in liver tissue regardless of the form of the administered selenium. On the other hand, selenium caused a decreased glutathione reductase level in the liver and metallothionein level in the liver, kidney and muscle. [...]

Keywords

EN

Selenium; Oxidative Stress; Glutathione; Glutathione Reductase; Metallothionein

• Publisher: De Gruyter Open
• Journal: Open Chemistry
• Year: 2012
• Volume: 10
• Issue: 5
• Pages: 1442-1451

Dates

published

1 - 10 - 2012

online

21 - 7 - 2012

Contributors

author

Jiri Sochor

author

Miroslav Pohanka

• Faculty of Military Health Sciences, University of Defence, 500 01, Hradec Kralove, Czech Republic

author

Branislav Ruttkay-Nedecky

author

Ondrej Zitka

author

David Hynek

author

Petr Mares

• Department of Animal Nutrition and Forage Production, Faculty of Agronomy, Mendel University in Brno, CZ-613 00, Brno, Czech Republic

author

Ladislav Zeman

• Department of Animal Nutrition and Forage Production, Faculty of Agronomy, Mendel University in Brno, CZ-613 00, Brno, Czech Republic

author

Vojtech Adam

author

Rene Kizek

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Identifiers

DOI

10.2478/s11532-012-0064-8