Synthesis and antimicrobial screening of pyrano[3,2-c]chromene derivatives of 1H-pyrazoles

• Authors: Chetan Sangani , Divyesh Mungra , Manish Patel , Ranjan Patel
• Languages of publication: EN

Abstracts

EN

A new series of twenty four derivatives of pyrano[3,2-c]chromene IVa-x bearing 1H-pyrazole were synthesized by a one pot, base-catalyzed cyclocondensation reaction of 1H-pyrazole-4-carbaldehyde Ia-l, malononitrile II and 4-hydroxycoumarin IIIa-b. All the synthesized compounds were characterized by elemental analysis, FT-IR, 1H NMR and 13C NMR spectral data. All the synthesized compounds were screened against six bacterial pathogens, namely B. subtilis, C. tetani, S. pneumoniae, S. typhi, V. cholerae, E. coli and for antifungal activity against two fungal pathogens, A. fumigatus and C. albicans using the broth microdilution MIC method. Some of the compounds were found to be equipotent or more potent than commercial drugs against most of employed strains, as evident from the screening data. [...]

Keywords

EN

Chromene; MCR; Pyrazole-4-carbaldehyde; Antimicrobial activity

• Publisher: De Gruyter Open
• Journal: Open Chemistry
• Year: 2011
• Volume: 9
• Issue: 4
• Pages: 635-647

Dates

published

1 - 8 - 2011

online

4 - 6 - 2011

Contributors

author

Chetan Sangani

• Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar, 388120, Gujarat, India

author

Divyesh Mungra

• Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar, 388120, Gujarat, India

author

Manish Patel

• Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar, 388120, Gujarat, India

author

Ranjan Patel

• Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar, 388120, Gujarat, India

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Identifiers

DOI

10.2478/s11532-011-0041-7