Conductometric studies on the stability of copper complexes with different oligosaccharides

• Authors: Ivan Savic , Goran Nikolic , Ivana Savic , Milorad Cakic
• Languages of publication: EN

Abstracts

EN

Bioactive copper complexes with pullulan or dextran oligosaccharides are the subject of intensive research mainly because of their possible application in veterinary and human medicine. The thermal stability and stability under oxidative conditions of the Cu(II) complexes with reduced low-molar pullulan or dextran were investigated in this paper, using a conductometric method. The influence of ligand constitutions on the stability of the complexes was examined on the basis of ligand property. Forced degradation studies were performed on bulk sample of complexes by using heat (25, 40 and 60°C) and an oxidation agent (0.1, 0.5, 1.0 and 10.0% v/v hydrogen peroxide). It can be concluded, according to the results obtained (by examining conductivity during the forced degradation studies), that Cu(II) complexes show a large pharmaceutical stability for both tests. [...]

Keywords

EN

Copper(II); Polysaccharide; Complex; Conductometry; Stability

• Publisher: De Gruyter Open
• Journal: Open Chemistry
• Year: 2010
• Volume: 8
• Issue: 5
• Pages: 1078-1085

Dates

published

1 - 10 - 2010

online

5 - 9 - 2010

Contributors

author

Ivan Savic

• Department of Pharmaceutics, Faculty of Technology, University of Nis, Leskovac, 16000, Serbia

author

Goran Nikolic

• Department of Pharmaceutics, Faculty of Technology, University of Nis, Leskovac, 16000, Serbia

author

Ivana Savic

• Department of Pharmaceutics, Faculty of Technology, University of Nis, Leskovac, 16000, Serbia

author

Milorad Cakic

• Department of Pharmaceutics, Faculty of Technology, University of Nis, Leskovac, 16000, Serbia

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Identifiers

DOI

10.2478/s11532-010-0082-3