A fast determination of yohimbine in pharmaceuticals by micellar electrokinetic chromatography

• Authors: Kateřina Vítková , Markéta Pechová , Jan Petr , Joanna Znaleziona , Václav Ranc , Vítězslav Maier , Juraj Ševčík
• Languages of publication: EN

Abstracts

EN

A method for the fast determination of yohimbine, a potent adrenoreceptor antagonist used for the treatment of sexual dysfunctions, is proposed in this article. MEKC under basic and acidic conditions (sodium borate, pH 9.5 and sodium phosphate, pH 2.5) with SDS was developed. The effect of the experimental parameters, e.g. pH, SDS concentration and injection time, on yohimbine migration was also studied. Both methods were validated in terms of linearity, limits of detection and quantification, accuracy, and precision using caffeine as an internal standard. The application for the determination of yohimbine in hand-made medicaments is also investigated in this study. [...]

Keywords

EN

Micellar electrokinetic chromatography; Yohimbine; Pharmaceuticals

• Publisher: De Gruyter Open
• Journal: Open Chemistry
• Year: 2010
• Volume: 8
• Issue: 2
• Pages: 273-277

Dates

published

1 - 4 - 2010

online

23 - 3 - 2010

Contributors

author

Kateřina Vítková

• Department of Analytical Chemistry, Faculty of Science, Palacký University in Olomouc, CZ-77146, Olomouc, Czech Republic

author

Markéta Pechová

• Department of Clinical Biochemistry, University Hospital Olomouc, CZ-77520, Olomouc, Czech Republic

author

Jan Petr

author

Joanna Znaleziona

• Department of Analytical Chemistry, Faculty of Science, Palacký University in Olomouc, CZ-77146, Olomouc, Czech Republic

author

Václav Ranc

• Department of Analytical Chemistry, Faculty of Science, Palacký University in Olomouc, CZ-77146, Olomouc, Czech Republic

author

Vítězslav Maier

• Department of Analytical Chemistry, Faculty of Science, Palacký University in Olomouc, CZ-77146, Olomouc, Czech Republic

author

Juraj Ševčík

• Department of Analytical Chemistry, Faculty of Science, Palacký University in Olomouc, CZ-77146, Olomouc, Czech Republic

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Identifiers

DOI

10.2478/s11532-009-0149-1