Synthesis and characterization of temperature-sensitive and biodegradable hydrogel based on N-isopropylacrylamide

• Authors: Yueqin Yu , Yanshun Li , Chunjing Zhu , Lingxiu Liu
• Languages of publication: EN

Abstracts

EN

Based on a biodegradable cross-linker, N-maleyl chitosan (N-MACH), a series of Poly(N-isopropylacrylamide) (PNIPAAm) and Poly(N-isopropylacrylamide-co-acrylamide) [P(NIPAAm-co-Am)] hydrogels were prepared, and their lower critical solution temperature (LCST), swelling kinetics, equilibrium swelling ratio in NaCl solution, and enzymatic degradation behavior in simulated gastric fluids (SGF) were discussed. The LCST did not change with different cross-linker contents. By altering the NIPAAm/Am molar ratio of P(NIPAAm-co-Am) hydrogels, the LCST could be increased to 39°C. The LCST of the hydrogel was significantly influenced by the monomer ratio of the NIPAAm/Am but not by the cross-linker content. In the swelling kinetics, all the dry hydrogels exhibited fast swelling behavior, and the swelling ratios were influenced by the cross-linker content and NIPAAm/Am molar ratios. Equilibrium swelling ratio of all the hydrogels decreased with increasing NaCl solution concentration. In enzymatic degradation tests, the weight loss of hydrogels was dependent on the cross-linker contents and the enzyme concentration. [...]

Keywords

EN

N-maleyl chitosan; N-isopropylacrylamide; LCST; Swelling kinetics; Enzymatic degradation

• Publisher: De Gruyter Open
• Journal: Open Chemistry
• Year: 2010
• Volume: 8
• Issue: 2
• Pages: 426-433

Dates

published

1 - 4 - 2010

online

23 - 3 - 2010

Contributors

author

Yueqin Yu

• Key Laboratory of Eco-chemical Engineering, Ministry of Education, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, 266042, P. R. China

author

Yanshun Li

• Key Laboratory of Eco-chemical Engineering, Ministry of Education, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, 266042, P. R. China

author

Chunjing Zhu

• Key Laboratory of Eco-chemical Engineering, Ministry of Education, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, 266042, P. R. China

author

Lingxiu Liu

• Key Laboratory of Eco-chemical Engineering, Ministry of Education, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, 266042, P. R. China

References

• [1] A.S. Hoffman, Adv. Drug Deliv. Rev. 43, 3 (2002) http://dx.doi.org/10.1016/S0169-409X(01)00239-3[Crossref]
• [2] L.M. Geever, D.M. Devine, M.J.D. Nugent, J.E. Kennedy, J.G. Lyons, Eur. Polym. J. 42, 2540 (2006) http://dx.doi.org/10.1016/j.eurpolymj.2006.06.002[Crossref]
• [3] Y. Kumashiro, K.M. Huh, T. Ooya, N. Yui, Biomacromolecules 2, 874 (2001) http://dx.doi.org/10.1021/bm015527y[Crossref]
• [4] T. Ito, T. Yamaguchi, Langmuir 22, 3945 (2006) http://dx.doi.org/10.1021/la053206s[Crossref]
• [5] H.J. Dai, Q. Chen, H.L. Qin, Y. Guan, Macromolecules 39, 6584 (2006) http://dx.doi.org/10.1021/ma060486p[Crossref]
• [6] H. Feil, Y.H. Bae, J. Feijen, S.W. Kim, Macromolecules 26, 2496 (1993) http://dx.doi.org/10.1021/ma00062a016[Crossref]
• [7] F.J. Xu, E.T. Kang, K.G. Neoh, Biomaterials 27, 2787 (2006) http://dx.doi.org/10.1016/j.biomaterials.2006.01.003[Crossref]
• [8] X.Z. Zhang, P.J. Lewis, C.C. Chu, Biomaterials 26, 3299 (2005) http://dx.doi.org/10.1016/j.biomaterials.2004.08.024[Crossref]
• [9] N.A. Peppas, R. Langer, Science 263, 1715 (1994) http://dx.doi.org/10.1126/science.8134835[Crossref]
• [10] P.S. Stayton, T. Shimobji, C. Long, A. Chilkoti, G. Chen, J.M. Harris, A.S. Hoffman, Nature 378, 472 (1995) http://dx.doi.org/10.1038/378472a0[Crossref]
• [11] Y. Qiu, K. Park, Adv. Drug Deliv. Rev. 53, 321 (2001) http://dx.doi.org/10.1016/S0169-409X(01)00203-4[Crossref]
• [12] T. Shiroya, N. Tamura, M. Yasui. K. Fujimoto, H. Kawaguchi, Colloids Surf. B 4, 267 (1995) http://dx.doi.org/10.1016/0927-7765(94)01177-7[Crossref]
• [13] H. Feil, Y.H. Bae, J. Feigen, S.W. Kim, J. Membr. Sci. 64, 283 (1991) http://dx.doi.org/10.1016/0376-7388(91)80099-R[Crossref]
• [14] F. Eeckman, A.J. Moes, K. Amighi, Eur. Polym. J. 40, 873 (2004) http://dx.doi.org/10.1016/j.eurpolymj.2003.11.010[Crossref]
• [15] X.Z. Zhang, G.M. Sun, D.Q. Wu, C.C. Chu, J. Mater. Sci. Mater. in Med. 15, 865 (2004) http://dx.doi.org/10.1023/B:JMSM.0000036274.83104.fe[Crossref]
• [16] S. Kim, K.E. Healy, Biomacromolecules 4, 1214 (2003) http://dx.doi.org/10.1021/bm0340467[Crossref]
• [17] D. Pantaleone, M. Yapani, Carbohydr. Res. 237,325 (1992) http://dx.doi.org/10.1016/S0008-6215(92)84256-R[Crossref]
• [18] M. Ryosuke, M. Michiaki, K. Kazuo, J. Chem. Eng. 29, 1044 (1996) http://dx.doi.org/10.1252/jcej.29.1044[Crossref]
• [19] P. Martens, A.T. Metters, K.S. Anseth, C.N. Bowman, J. Phys. Chem. B 105, 5131 (2001) http://dx.doi.org/10.1021/jp004102n[Crossref]
• [20] Y.M. Dong, et al., Polym. Int. 55, 1444 (2006) http://dx.doi.org/10.1002/pi.2099[Crossref]
• [21] X. Jiang, L. Chen, W. Zhong, Carbohydr. Polym. 54, 457 (2003) http://dx.doi.org/10.1016/j.carbpol.2003.05.004[Crossref]
• [22] H.G. Schild, D.A. Tirrell, J. Phys. Chem. 94, 4352 (1990) http://dx.doi.org/10.1021/j100373a088[Crossref]
• [23] G.H. Chen, A.S. Hoffman, Nature 373, 49 (1995) http://dx.doi.org/10.1038/373049a0[Crossref]
• [24] X.Z. Zhang, G.M. Sun, D.Q. Wu, J. Mater. Sci. Mater. in Med. 15, 865 (2000) http://dx.doi.org/10.1023/B:JMSM.0000036274.83104.fe[Crossref]
• [25] X.H. Feng, R. Pelton, Macromolecules 40, 1624 (2007) http://dx.doi.org/10.1021/ma062608j[Crossref]

Identifiers

DOI

10.2478/s11532-009-0144-6