Synthesis and structural characterization of amino-functionalized polysaccharides

• Authors: Ioana Sisu , Valentina Udrescu , Corina Flangea , Sorin Tudor , Nicolae Dinca , Lucian Rusnac , Alina Zamfir , Eugen Sisu
• Languages of publication: EN

Abstracts

EN

A variety of carbohydrates, in particular polysaccharides can be subjected to chemical modification to obtain derivatives with amphiphilic properties, which enable biochemical or biological reactions at the polymer surface. In the present work, a polydisperse maltodextrin mixture of average molecular weight 3000 was coupled with 1,6-hexamethylenediamine (HMD) via reductive amination reaction. Resulting products were characterized by thermal analysis and positive nanoelectrospray quadrupole time-of-flight (Q-TOF) mass spectrometry (MS) and tandem mass spectrometry (MS/MS). Both thermal analysis and MS screening confirmed the formation of the HMD-polysaccharide coupling products. Moreover, HMD-linked polysaccharide chains containing 2 to 26 glucose building blocks were identified by nanoESI Q-TOF MS. MS/MS fragmentation using collision-induced dissociation (CID) at low ion acceleration energies provided strong evidence for HMD-maltodextrin linkage formation and the set of sequence ions diagnostic for the composition and structure of a HMD-linked chain containing 18 glucose residues. [...]

Keywords

EN

Polysaccharides; Synthesis; Thermal analysis; Electrospray ionization; Quadrupole time-of-flight tandem mass spectrometry

• Publisher: De Gruyter Open
• Journal: Open Chemistry
• Year: 2009
• Volume: 7
• Issue: 1
• Pages: 66-73

Dates

published

1 - 3 - 2009

online

23 - 12 - 2008

Contributors

author

Ioana Sisu

• Institute of Chemistry, Romanian Academy, RO-300223, Timisoara, Romania

author

Valentina Udrescu

author

Corina Flangea

author

Sorin Tudor

• Department of Chemical and Biological Sciences, “Aurel Vlaicu” University of Arad, Romania, RO-310130, Arad, Romania

author

Nicolae Dinca

• Department of Chemical and Biological Sciences, “Aurel Vlaicu” University of Arad, Romania, RO-310130, Arad, Romania

author

Lucian Rusnac

• Faculty of Industrial Chemistry and Environment Engineering, “Politehnica” University of Timisoara, RO-300030, Timisoara, Romania

author

Alina Zamfir

author

Eugen Sisu

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Identifiers

DOI

10.2478/s11532-008-0090-8