Synthesis of Xenbucin using Suzuki reaction catalyzed by Pd/C in water

• Authors: Noora Kuuloja , Tuula Kylmälä , Youjun Xu , Robert Franzén
• Languages of publication: EN

Abstracts

EN

Xenbucin 1, an analgesic drug, was synthesized in 4 steps using two different routes. The biaryl fragment could successfully be produced via a Pd/C catalysed Suzuki coupling in water using sodium tetraphenylborate as a phenylation reagent. Overall yields of the routes were 36% and 59%, respectively. [...]

Keywords

EN

Xenbucin; Suzuki coupling; Pd/C; Sodium tetraphenylborate; NSAID

• Publisher: De Gruyter Open
• Journal: Open Chemistry
• Year: 2008
• Volume: 6
• Issue: 3
• Pages: 390-392

Dates

published

1 - 9 - 2008

online

11 - 8 - 2008

Contributors

author

Noora Kuuloja

• Department of Chemistry and Bioengineering, Tampere University of Technology, 33101, Tampere, Finland

author

Tuula Kylmälä

• Department of Chemistry and Bioengineering, Tampere University of Technology, 33101, Tampere, Finland

author

Youjun Xu

• School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, 110016, China

author

Robert Franzén

• Department of Chemistry and Bioengineering, Tampere University of Technology, 33101, Tampere, Finland

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Identifiers

DOI

10.2478/s11532-008-0044-1