Synthesis and pharmacological properties of 3-(2-methyl-furan-3-yl)-4-substituted-Δ2-1,2,4-triazoline-5-thiones

• Authors: Agata Siwek , Monika Wujec , Maria Dobosz , Ewa Jagiełło-Wójtowicz , Anna Chodkowska , Agnieszka Kleinrok , Piotr Paneth
• Languages of publication: EN

Abstracts

EN

By the reaction of 2-methyl-furan-3-carboxylic acid hydrazide with isothiocyanates, 1-[(2-methyl-furan-3-yl)carbonyl]-4-substituted thiosemicarbazides 1 were obtained. Further cyclization with 2% NaOH led to the formation of 3-(2-methyl-furan-3-yl)-4-substituted-Δ2-1,2,4-triazoline-5-thiones 2. The pharmacological effects of 2 on the central nervous system in mice were investigated. Strong antinociceptive properties of the investigated derivatives were observed in a wide range of doses. [...]

Keywords

EN

Δ2-1,2,4-triazoline-5-thione; CNS activity; DFT

• Publisher: De Gruyter Open
• Journal: Open Chemistry
• Year: 2008
• Volume: 6
• Issue: 1
• Pages: 47-53

Dates

published

1 - 3 - 2008

online

1 - 3 - 2008

Contributors

author

Agata Siwek

• Department of Organic Chemistry, Faculty of Pharmacy, Medical University, Staszica 6, 20-081, Lublin, Poland

author

Monika Wujec

• Department of Organic Chemistry, Faculty of Pharmacy, Medical University, Staszica 6, 20-081, Lublin, Poland

author

Maria Dobosz

• Department of Organic Chemistry, Faculty of Pharmacy, Medical University, Staszica 6, 20-081, Lublin, Poland

author

Ewa Jagiełło-Wójtowicz

• Department of Toxicology, Medical University, 20-093, Lublin, Poland

author

Anna Chodkowska

• Department of Toxicology, Medical University, 20-093, Lublin, Poland

author

Agnieszka Kleinrok

• Department of Toxicology, Medical University, 20-093, Lublin, Poland

author

Piotr Paneth

• Department of Computer Science, Academy of Humanities and Economics in Lodz, 90-222, Lodz, Poland

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Identifiers

DOI

10.2478/s11532-007-0058-0