Dopamine and iron mediated fragmentation of galactocerebroside and cardiolipin in micelles

• Authors: Irina Yurkova , Mikhail Kisel , Juergen Arnhold , Oleg Shadyro
• Languages of publication: EN

Abstracts

EN

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) and thin-layer chromatography (TLC) have been used to study dopamine and iron mediated free-radical transformation of lipids in their hydrophilic parts. It has been shown that the action of the dopamine/Fe2+ system on galactocerebroside or cardiolipin, which are the components of mixed micelles, results in formation of ceramide or phosphatidic acid and phosphatidylhydroxyacetone, respectively. These data, when combined with results obtained using the ascorbate/Fe2+/H2O2 oxidizing system with the same substrates, demonstrate that the formation of these products proceeds via an OH-radical induced fragmentation taking place in polar moiety of the starting lipids. [...]

Keywords

EN

free-radical fragmentation; lipids; MALDI-TOF MS; thin-layer chromatography

• Publisher: De Gruyter Open
• Journal: Open Chemistry
• Year: 2007
• Volume: 5
• Issue: 4
• Pages: 970-980

Dates

published

1 - 12 - 2007

online

1 - 12 - 2007

Contributors

author

Irina Yurkova

• Research Institute for Physical Chemical Problems of the Belarusian State University, Leningradskaya str. 14, 220050, Minsk, Belarus

author

Mikhail Kisel

• Institute of Bioorganic Chemistry, Belarus National Academy of Sciences, Kuprevicha str. 5/2, 220080, Minsk, Belarus

author

Juergen Arnhold

• Institute of Medical Physics and Biophysics, Medical Department, University of Leipzig, Härtelstr. 16-18, D-04107, Leipzig, Germany

author

Oleg Shadyro

• Research Institute for Physical Chemical Problems of the Belarusian State University, Leningradskaya str. 14, 220050, Minsk, Belarus

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Identifiers

DOI

10.2478/s11532-007-0041-9