Voltammetric quantitation at the mercury electrode of the anticholinergic drug flavoxate hydrochloride in bulk and in a pharmaceutical formulation

• Authors: M.M. Ghoneim , M.A. El-Attar , S.A. Razeq
• Languages of publication: EN

Abstracts

EN

Flavoxate hydrochloride, 2-piperidinoethyl 3-methyl-4-oxo-2-phenyl-4-H-chromene-8-carboxylate, is a smooth muscle antispasmodic. Its electrochemical behavior was studied at the mercury electrode in buffered solutions containing 30% (v/v) methanol using dc-polarography, differential-pulse polarography, cyclic voltammetry, and linear sweep-and square-wave adsorptive stripping voltammetry. Sensitive and precise procedures were developed for determination of bulk flavoxate hydrochloride and in the pharmaceutical formulation Genurin® S.F, without sample pretreatment or extraction. Limits of quantitation (LOQ) of 1 × 10−5, 5 × 10−6, 1 × 10−8 and 1 × 10−9 M flavoxate hydrochloride were achieved by dc-polarography, differential-pulse polarography, linear sweep and square-wave adsorptive stripping voltammetric, respectively. [...]

Keywords

EN

Flavoxate hydrochloride; Genurin® tablets; polarography; cyclic voltammetry; adsorptive stripping voltammetry; quantitation

• Publisher: De Gruyter Open
• Journal: Open Chemistry
• Year: 2007
• Volume: 5
• Issue: 2
• Pages: 496-507

Dates

published

1 - 6 - 2007

online

2 - 2 - 2007

Contributors

author

M.M. Ghoneim

• Analytical Chemistry Research Unit, Chemistry Department, Faculty of Science, Tanta University, 31527, Tanta, Egypt

author

M.A. El-Attar

• Analytical Chemistry Research Unit, Chemistry Department, Faculty of Science, Tanta University, 31527, Tanta, Egypt

author

S.A. Razeq

• Department of Analytical Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, 11754, Nacer City-Cairo, Egypt

References

• [1] E. Pedersen: ”Studies on effect and mode of action of flavoxate in human urinary bladder and sphincter”, Urol. Int., Vol. 32, (1977), pp. 202–208. http://dx.doi.org/10.1159/000280131[Crossref]
• [2] D.V Bradley and R.J. Cazort: ”Relief of bladder spasm by flavoxate: A comparative study”, J. Clin. Pharm. & New Drugs, Vol. 10, (1970), pp. 65–68.
• [3] A. Gova and I. Setnikar: ”Flavoxate and 3-methylflavone-8-carboxylic acid. Assay methods in blood plasma red cells repartition and stability”, Drug Research, Vol. 25, (1975), pp. 1707–1709.
• [4] C.X. Zhang, Z.P. Sun and D.K. Ling: ”Determination of 3-methylflavoxate in human urine by capillary electrophoresis with direct injection”, J. Chromatogr., Vol. 612 (1993), pp. 287–294. http://dx.doi.org/10.1016/0378-4347(93)80175-4[Crossref]
• [5] M.T. Sheu, G.C. Yeh, W.T. Ke and H.O. Ho: ”Development of a high-performance liquid chromatographic method for bioequivalence study of flavonate tablets”, Chromatogr. B, Vol. 751, (2001), pp. 79–86. http://dx.doi.org/10.1016/S0378-4347(00)00451-5[Crossref]
• [6] L. Meites: Polarographic Techniques, 2nd ed., Interscience, New York, 1965, p. 232.
• [7] H.T.S. Britton: Hydrogen Ions, 4th ed., Chapman & Hall, London, 1952, p. 113.
• [8] P. Zuman: The Elucidation of Organic Electrode Processes, Academic Press, New York, 1969, pp. 20–24.
• [9] M.M. Ghoneim and M.A. Ashy: ”Polarographic reduction of phenolphthalein, cresolphthalein, thymolphthalein and α-naphtholphthalein in aqueous and nonaqueous solutions”, Can. J. Chem., Vol. 57, (1979), pp. 1294–1298. http://dx.doi.org/10.1139/v79-212[Crossref]
• [10] J.N. Miller: ”Basic statistical methods for analytical chemistry. 2. Calibration and regression methods - A review”, Analyst, Vol. 116, (1991), pp. 3–14 http://dx.doi.org/10.1039/an9911600003[Crossref]
• [11] Southampton Electrochemistry Group: Instrumental methods in electrochemistry, Ellis Horwood Limited, Chichester, 1985, pp. 185–189.
• [12] E.A. Laviron: ”A multilayer mode for the study of space distributed redox modified electrodes. Part II. Theory and application of linear potential sweep voltammetry for a simple reaction”, J. Electroanal. Chem., Vol. 112, (1980), pp. 11–23. http://dx.doi.org/10.1016/S0022-0728(80)80003-9[Crossref]
• [13] A. Webber and J. Osteryoung: ”Cathodic reduction of nicotinamide adeninedinucleotide and their adenine-containing compounds in acidic media”, Anal. Chem. Acta, Vol. 157, (1984), pp. 17–29. http://dx.doi.org/10.1016/S0003-2670(00)83601-6[Crossref]
• [14] National Formulary (USP-26), US Pharmacopoeia - 2003, The United States Pharmacopeial Convention, Inc., Rockville, MD, 2003, p. 2446.
• [15] G.W. Ewing: Instrumental Methods of Chemical Analysis, 5th ed., Lippincott-Raven, Philadelphia, 1995, p. 464.
• [16] G.D. Christian: Analytical Chemistry, 5th ed., John Wiley & Sons Inc., New York, 1994, p. 36.

Identifiers

DOI

10.2478/s11532-007-0011-2