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2015 | 124 | 3 | 160-163

Article title

The Biomedical Role of Zinc in the Functioning of the Human Organism

Content

Title variants

Languages of publication

EN

Abstracts

EN
Zinc is one of the most important microelements that can be found in the human organism. It is a component or an activator of various enzymes and takes part in more than 300 enzymatic reactions. It is present in all types of human tissue. About 90% of the general amount of zinc can be found in bones and muscles, 11% in liver and skin. Zn2+ ions are stable ions in biological environment and they do not participate in redox reactions that occur inside an organism. Assimilability of this element by living organisms is varied. It depends largely on the sort of food and interactions occurring between zinc and other elements. Zinc is an essential element for normal development and maintenance of human health.The data presented in this article result from an overview of studies presented in literature published in the last five years concerning zinc transport mechanisms, the role of zinc in functioning of the human body, and also pathophysiological states caused by too low or excessive concentration of zinc in an organism.

Publisher

Year

Volume

124

Issue

3

Pages

160-163

Physical description

Dates

online
10 - 12 - 2014

Contributors

  • Chair of Public Health of the Technical University in Częstochowa, Poland
  • Chair of Public Health of the Technical University in Częstochowa, Poland

References

  • 1. Ślęzak A, Zyska A. Rola jonów cynku w funkcjonowaniu organizmu człowieka. Żywienie Człow Metab. 2006;1:91-9.
  • 2. Kabata-Pendias A, Pendias H. Biogeochemia pierwiastków śladowych. Warszawa: Wyd. Nauk. PWN;1999. p.145-56.
  • 3. Plum L, Rink L, Haase H. The essential toxin: impact of zinc on human health. Int J Environ Res Public Health. 2010;7:1342-65.[Crossref][PubMed]
  • 4. Chasapis C, Loutsidou A, Spiliopoulou C, Stefanidou M. Zinc and human health: an update. Arch Toxicol. 2012;86:521-34.[Crossref][WoS][PubMed]
  • 5. Puzanowska-Tarasiewicz H, Kuźmicka L, Tarasiewicz M. Funkcje biologiczne wybranych pierwiastków. III. Cynk – składnik i aktywator enzymów. Pol Merk Lek. 2009;161:419-22.
  • 6. Turek M, Łodyga-Chruścinska E. Zastosowanie w medycynie po-chodnych indolu i jego kompleksów z biometalami. Food Chemistry and Biotechnol. 2008;72:73-88.
  • 7. Prasad A. Impact of the Discovery of Human Zinc Deficiency on Health. J Am Coll Nutr. 2009;28:257-65.[PubMed][Crossref]
  • 8. Sekler I, Sensi S, Hershfinkel M, Silverman W. Mechanism and Regulation of Cellular Zinc Trasport. Mol Med. 2007;13:337-43.[WoS]
  • 9. Kambe T, Weaver B, Andrews G. The Genetics of Essential Metal Ho-meostasis During Development. Genesis. 2009;46:214-28.[WoS]
  • 10. Yamasaki S, Sakata-Sogawa K, Hasegawa A, et al. Zinc is a novel intra-cellular second messenger. J Cell Biol. 2007;177:637-45.[WoS]
  • 11. Hediger MA, Romero MF, Peng JB, et al. The ABCs of solutecarriers: physiological, pathological and therapeuticimplications of humanmem-branetransport proteins. Introduction. Pflugers Arch. 2004;447:465-8.
  • 12. Lichten L, Cousins RJ. Mammalian zinc transporters: nutritional and physiologic regulation. Annu Rev Nutr. 2009;29:153-76.[WoS][PubMed][Crossref]
  • 13. Tuerk MJ, Fazel N. Zinc defciency. Curr Opin Gastroenterol. 2009;25:136-43.[Crossref]
  • 14. Ślęzak A, Zyska A. Cynk a choroby środowiskowe. In: A. Ślęzak, J. Jasik-Ślęzak (ed). Biomedyczne problemy zdrowia publicznego. Częstochowa: Wyższa Szkoła Hotelarstwa i Turystyki w Częstochowie; 2008. p. 137-47.
  • 15. Barany E, Bergdahl I, Bratteby L, et al. Relationships between trace element concentrations in human blood and serum. Toxicology Letters. 2002;134:177-84.
  • 16. Zhao J, Bertoglio B, Gee K, Kay A. The zinc indicator FluoZin-3 is not perturbed significantly by physiological levels of calcium or magnesium. Cell Calcium. 2008;44:422-6.[WoS][PubMed][Crossref]
  • 17. Bagherani N, Yaghoobi R, Omidian M. Hypothesis: zinc can be effective in treatment of vitiligo. Indian J Dermatol. 2011;56:480-4.[Crossref][PubMed]
  • 18. Bhasin P, Singla N, Dhawan DK. Protective role of zinc during aluminum-induced hepatotoxicity. Environ Toxicol. 2012;doi:10.1002/ tox.21760.[Crossref][PubMed][WoS]
  • 19. Gertig H, Przysławski J. Bromatologia. Zarys nauk o żywności i żywieniu. Warszawa: Wydawnictwo Lekarskie PZWL; 2007. p. 216-21.
  • 20. Adamo AM, Oteiza PI. Zinc deficiency and neurodevelopment: the case of neurons. Biofactors. 2010;36:117-24.[WoS][PubMed]
  • 21. Arιca S, Arιca V, Dag H, Kaya A, et al. Serum zinc levels in children of 0-24 months diagnosed with pneumonia admitted to our clinic. Int J Clin Exp Med. 2011;4:227-33.
  • 22. Kelishadi R, Hashemipour M, Adeli K, et al. Effect of zinc supplementation on markers of insulin resistance, oxidative stress, and inflammation among prepubescent children with metabolic syndrome. Metab Syndr Relat Disord. 2010;8:505-10.[WoS]
  • 23. Ortega RM, Rodríguez-Rodríguez E, Aparicio A, et al. Poor zinc status is associated with increased risk of insulin resistance in Spanish chil-dren. Br J Nutr. 2012;107:398-404.[Crossref]
  • 24. Bajait C, Thawani V. Role of zinc in pediatric diarrhea. Indian J Pharmacol. 2011;43:232-5.[PubMed][WoS]
  • 25. Memon AU, Kazi TG, Afridi HI, et al. Evaluation of zinc status in whole blood and scalp hair of female cancer patients. Clin Chim Acta. 2007;379:66-70.[WoS]
  • 26. Takeda A, Tamano H, Ogawa T, Takada S, et al. Significance of serum glucocorticoid and chelatable zinc in depression and cognition in zinc deficiency. Behav Brain Res. 2012;226:259-64.[WoS]
  • 27. Wang C Y, Wang T, Zheng W, et al. Zinc overload enhances APP cleavage and Ab deposition in the Alzheimer mouse brain. PLoS One. 2010;5:15349.[WoS][Crossref]
  • 28. Amani R, Saeidi S, Nazari Z, Nematpour S. Correlationbetween dietary zinc intakes and its serum levels with depression scales in young female students. Biol Trace Elem Res. 2010;137:150-8.[WoS]
  • 29. Siwek M, Dudek D, Zięba A, Nowak G. Stężenie cynku w surowicy jako obwodowy marker zaburzeń depresyjnych. Farmakoter Psychiatr Neurol. 2006;3:141-9.
  • 30. Jayawardena R, Ranasinghe P, Galappatthy P, et al. Effects of zinc supplementation on diabetes mellitus: a systematic review and meta-analy-sis. Diabetol Metab Syndr. 2012;4:13.
  • 31. Zdrojewicz Z, Wiśniewska A. Rola cynku w seksualności mężczyzn. Adv Clin Exp Med. 2005;14:1295-300.
  • 32. Kawade R. Zinc status and its association with the health of adolescents: a review of studies in India. Glob Health Action. 2012,doi: 10.3402/gha. v5i0.7353.[PubMed][WoS][Crossref]
  • 33. Driscoll ER, Bettger WJ. The effect of dietary zinc deficiency in the rat on the lipid composition of the erythrocyte membrane Triton Shell. Lipids. 1993;27:972-7.
  • 34. John E, Laskow T, Buchser W, et al. Zinc in innate and adaptive tumor immunity. J Transl Med. 2010;8:118.[PubMed][Crossref]
  • 35. Prasad A. Zinc and Human Health: Effect of Zinc on Immune Cells. Mol Med. 2008;14:353-7.[PubMed][WoS]
  • 36. Afridi HI, Kazi TG, Kazi N, et al. Evaluation of zinc, copper and iron in biological samples (scalp hair, blood and urine) of tuberculosis and diarrhea male human immunodeficiency virus patients. Clin Lab. 2011;57:677-88.[PubMed]

Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.-psjd-doi-10_2478_pjph-2014-0036
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