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2012 | 1 | 35-40

Article title

Twenty years since ‘antibody mimics’ by molecular imprinting
were first proposed: A critical perspective

Content

Title variants

Languages of publication

EN

Abstracts

EN
In February 1993, the group of Klaus Mosbach published their milestone
study in Nature where, for the first time, non-covalent molecular imprints
were employed in a competitive binding assay. In this seminal piece
of work, and also for the first time, they refer to molecularly imprinted
polymers as being ‘antibody mimics’ and hypothesised that these synthetic
materials could one day provide ‘a useful, general alternative to antibodies’.
This perspective article examines how far we have come in the 20 years
since this publication in terms of realising this hypothesis and poses the
question of whether we actually need molecularly imprinted polymers to be
a general alternative to antibodies.

Publisher

Year

Volume

1

Pages

35-40

Physical description

Dates

received
12 - 12 - 2012
accepted
15 - 02 - 2013
online
27 - 02 - 2013

Contributors

  • Cardiff School of Pharmacy
    and Pharmaceutical Sciences,
    Cardiff University, King Edward VII Avenue,
    Cardiff, CF10 3NB, United Kingdom
  • Department of Chemistry and Chemical
    Engineering, Queen’s University Belfast,
    David Keir Building, Stranmillis Road,
    Belfast BT9 5AG, United Kingdom
  • Cardiff School of Pharmacy
    and Pharmaceutical Sciences,
    Cardiff University, King Edward VII Avenue,
    Cardiff, CF10 3NB, United Kingdom

References

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  • Vlatakis G., et al., Drug assay using antibody mimics madeby molecular imprinting. Nature, 1993, 361(6413), 645-647.
  • Alexander C., et al., Molecular imprinting science andtechnology: a survey of the literature for the years up to andincluding 2003. J. Mol. Recognit., 2006, 19(2), 106-180.
  • MIP Database. (accessed: 05/02/2012); Available from:www.mipdatabase.com.
  • Pichon V. and Chapuis-Hugon F., Role of molecularlyimprinted polymers for selective determination ofenvironmental pollutants - A review. Anal. Chim. Acta, 2008,622(1-2), 48-61.
  • Manesiotis P., et al., Applications of SPE-MIP in the fieldof food analysis, in Comprehensive Sampling and SamplePreparation, J. Pawliszyn, Editor. 2012, Elsevier.
  • Manesiotis P., Osmani Q., and McLoughlin P., An enantioselectivechromatographic stationary phase for S-ibuprofenprepared by stoichiometric molecular imprinting. J. Mater.Chem., 2012, 22(22), 11201-11207.[WoS][Crossref]
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  • Sellergren B., ed. Molecularly Imprinted Polymers - Manmademimics of antibodies and their applications in analyticalchemistry. 2001, Elsevier.
  • Haupt K. and Mosbach K., Plastic antibodies: developmentsand applications. Trends Biotechnol., 1998, 16(11), 468-475.[PubMed][Crossref]
  • Saper C.B., An open letter to our readers on the use ofantibodies. J. Comp. Neurol., 2005, 493(4), 477-478.
  • Couchman J.R., Commercial antibodies: The good, bad,and really ugly. J. Histochem. Cytochem., 2009, 57(1), 7-8.[WoS]
  • Coico R. and Sunshine G., Immunology: A Short Course. 6thed. 2009: Wiley-Blackwell.
  • Manesiotis P., et al., Water-compatible imprinted polymersfor selective depletion of riboflavine from beverages. J.Mater. Chem., 2009, 19(34), 6185-6193.[WoS]
  • Asanuma H., Hishiya T., and Komiyama M., Tailor-madereceptors by molecular imprinting. Adv. Mater., 2000, 12(14),1019-1030.[Crossref]
  • Janiak D.S. and Kofinas P., Molecular imprinting of peptidesand proteins in aqueous media. Anal. Bioanal. Chem., 2007,389(2), 399-404.
  • Manesiotis P., et al., An artificial riboflavin receptor preparedby a template analogue imprinting strategy. Angew. Chem.,Int. Ed. Engl., 2005, 44(25), 3902-3906.[Crossref]
  • Nicholls I.A. and Andersson H.S., Thermodynamic principlesunderlying molecularly imprinted polymer formulation andligand recognition, in Molecularly Imprinted Polymers -Man-made Mimics of Antibodies and their Applications inAnalytical Chemistry, B. Sellergren, Editor. 2001, Elsevier.
  • Turner N.W., et al., From 3D to 2D: A review of the molecularimprinting of proteins. Biotechnol. Prog., 2006, 22(6), 1474-1489.[PubMed][Crossref]
  • Bossi A., et al., Molecularly imprinted polymers for therecognition of proteins: The state of the art. Biosens.Bioelectron., 2007, 22(6), 1131-1137.[PubMed][Crossref]
  • Hart B.R. and Shea K.J., Synthetic peptide receptors:Molecularly imprinted polymers for the recognition ofpeptides using peptide-metal interactions. J. Am. Chem.Soc., 2001, 123(9), 2072-2073.
  • Kempe M., Glad M., and Mosbach K., An approach towardssurface imprinting using the enzyme ribonuclease A. J. Mol.Recognit., 1995, 8(1-2), 35-9.[Crossref]
  • Mallik S., et al., Towards materials for the specific recognition andseparation of proteins. New J. Chem., 1994, 25(30), 299-304.
  • Titirici M.M., Hall A.J., and Sellergren B., Hierarchicalimprinting using crude solid phase peptide synthesisproducts as templates. Chem. Mater., 2003, 15(4), 822-824.[Crossref]
  • Titirici M.M. and Sellergren B., Peptide recognition viahierarchical imprinting. Anal. Bioanal. Chem., 2004, 378(8),1913-1921.
  • Rachkov A. and Minoura N., Recognition of oxytocinand oxytocin-related peptides in aqueous media using amolecularly imprinted polymer synthesized by the epitopeapproach. J. Chromatogr. A., 2000, 889(1-2), 111-118.
  • Rachkov A. and Minoura N., Towards molecularly imprintedpolymers selective to peptides and proteins. The epitopeapproach. Biochim. Biophys. Acta, 2001, 1544(1-2), 255-266.
  • Nishino H., Huang C.-S., and Shea K.J., Selective proteincapture by epitope imprinting. Angew. Chem., Int. Ed. Engl.,2006, 45(15), 2392-2396.[Crossref]
  • Hoshino Y., et al., Recognition, neutralization, andclearance of target peptides in the bloodstream of livingmice by molecularly imprinted polymer nanoparticles: Aplastic antibody. J. Am. Chem. Soc., 2010, 132(19), 6644-6645.[WoS]
  • Hoshino Y., et al., Peptide imprinted polymer nanoparticles: Aplastic antibody. J. Am. Chem. Soc., 2008, 130(46), 15242-15243.
  • Hoshino Y., et al., Design of synthetic polymer nanoparticlesthat capture and neutralize a toxic peptide. Small, 2009,5(13), 1562-1568.[WoS][PubMed][Crossref]
  • Cutivet A., et al., Molecularly imprinted microgels as enzymeinhibitors. J. Am. Chem. Soc., 2009, 131(41), 14699-14702.

Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.-psjd-doi-10_2478_molim-2013-0001
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