Genetics of myocardial infarction in clinical practice. Is it ready for prime time?

• Authors: M. Francesca Notarangelo , Federico Bontardelli , Rossella Giacalone , Angela Guidorossi , Vittoria Caporale , Diego Ardissino
• Languages of publication: EN

Abstracts

EN

Ischemic heart diseases are the leading cause of morbidity and mortality in developed countries, despite advances in cardiac care over the last few decades. Myocardial infarction is a complex, multifactorial disorder that is thought to be due to interactions between genetic and environmental factors. Recent rapid advances in molecular genetics techniques have identified a number of common genetic variants loosely associated with myocardial infarction, and highly promising, newly designed platforms should identify less common genetic variants with an even greater clinical impact. These discoveries have brought us to a stage at which we need to begin to consider how personalised genomic information should be incorporated into clinical practice in order to benefit individuals and society in general.

Keywords

EN

myocardial infarction; chromosome 9p21; genome-wide association study; genetic risk score

• Publisher: De Gruyter Open
• Journal: Genetics of Multifactorial Disorders
• Year: 2014
• Volume: 1
• Pages: 1-5

Dates

accepted

2 - 10 - 2013

online

24 - 02 - 2014

received

5 - 6 - 2013

Contributors

author

M. Francesca Notarangelo

• Division of Cardiology, Azienda Ospedaliero-Universitaria di Parma, Via Gramsci 14, 43126, Parma, Italy

author

Federico Bontardelli

• Division of Cardiology, Azienda Ospedaliero-Universitaria di Parma, Via Gramsci 14, 43126, Parma, Italy

author

Rossella Giacalone

• Division of Cardiology, Azienda Ospedaliero-Universitaria di Parma, Via Gramsci 14, 43126, Parma, Italy

author

Angela Guidorossi

• Division of Cardiology, Azienda Ospedaliero-Universitaria di Parma, Via Gramsci 14, 43126, Parma, Italy

author

Vittoria Caporale

• Division of Cardiology, Azienda Ospedaliero-Universitaria di Parma, Via Gramsci 14, 43126, Parma, Italy

author

Diego Ardissino

• Division of Cardiology, Azienda Ospedaliero-Universitaria di Parma, Via Gramsci 14, 43126, Parma, Italy

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Identifiers

DOI

10.2478/gmd-2014-0001