Collagenases and gelatinases in bone healing. The focus on mandibular fractures

• Authors: Jacek Kurzepa , Marcin Baran , Slawomir Watroba , Malgorzata Barud , Daniel Babula
• Languages of publication: EN

Abstracts

EN

Due to high amount of collagen fibres in the structure of bone, the enzymes capable of collagen digestion play a key role in bone remodelling. Matrix metalloproteinases (MMPs), prevailing extracellular endopeptideses, can digest extracellularly located proteins, e.g. collagen, proteoglycans, elastin or fibronectin. Among MMPs, collagenases (MMP-1, MMP-8 and MMP-13) and gelatinases (MMP-2 and MMP-9) can cleave collagen particles to forms that are able to undergo further steps of catabolism intracellularly. In addition, activity of the gelatinases (as an activation of proinflammatory cytokines) facilitates spreading inflammation that is necessary during the first stage of bone healing. Further studies related to the role of various MMPs in mandibular fractures should precisely explain their function in the bone healing and evaluate the influence of MMPs inhibitors on that process. This review provides the basic information about two groups among MMPs family, collagenases and gelatinases, and their role in repairing processes after mandibular fractures.

Keywords

EN

MMP-1; MMP-8; MMP-13; MMP-2; MMP-9; collagenases; gelatinases; mandibular fractures

• Publisher: De Gruyter Open
• Journal: Current Issues in Pharmacy and Medical Sciences
• Year: 2014
• Volume: 27
• Issue: 2
• Pages: 121-126

Dates

published

1 - 6 - 2014

received

17 - 6 - 2014

online

25 - 11 - 2014

accepted

7 - 8 - 2014

Contributors

author

Jacek Kurzepa

• Department of Medical Chemistry, Medical University of Lublin, Poland

author

Marcin Baran

• Department of Maxillofacial Surgery, Medical University of Lublin, Poland

author

Slawomir Watroba

• Department of Obstetrics and Perinatology, Medical University of Lublin, Poland

author

Malgorzata Barud

• Department of Medical Chemistry, Medical University of Lublin, Poland

author

Daniel Babula

• Department of Neurosurgery and Neurotraumatology, Saint Edvige Provincial Hospital No 2 in Rzeszow, Poland

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Identifiers

DOI

10.2478/cipms-2014-0029