The effect of hormone replacement therapy on the expression of the alkaline phosphatase gene (ALPL) within the mucosal epithelium of the cheek and in peripheral blood lymphocytes

• Authors: Mansur Rahnama , Michal Lobacz , Anna Szyszkowska , Grzegorz Trybek , Maryla Kozicka-Czupkallo
• Languages of publication: EN

Abstracts

EN

In adult life, proper bone metabolism requires efficient regulation of bone formation and resorption processes. Bone turnover markers allow for assessing the rate of bone formation and resorption processes. In menopausal period, female patients experience gradual reduction in blood estradiol levels. The deficit of estrogens leads to enhanced osteoclastogenesis and bone resorption. Alkaline phosphatase (ALP) is a membranebound enzyme that stimulates the osteoblast activity and bone mineralization. It is synthesized by osteoblasts and incorporated into the newly formed bone tissue. The produced enzyme stimulates the osteoblast activity and bone mineralization. The goal of this study is to determine the effect of hormone replacement therapy in postmenopausal women on the expression of alkaline phosphatase gene (ALPL) within the mucosal epithelium of the cheek and in peripheral blood lymphocytes. The studies show that hormone replacement therapy has no significant effect on the increase in ALPL expression within the mucosal epithelium of the cheek. Only in women having undergone ovarectomy (OV), the epithelial ALPL expression level was higher than in the remaining groups.

Keywords

EN

alkaline phosphatase; bone turnover markers; menopausal period; ovarectomy hormone replacement therapy

• Publisher: De Gruyter Open
• Journal: Current Issues in Pharmacy and Medical Sciences
• Year: 2014
• Volume: 27
• Issue: 2
• Pages: 92-96

Dates

published

1 - 6 - 2014

received

1 - 7 - 2014

accepted

11 - 8 - 2014

online

25 - 11 - 2014

Contributors

author

Mansur Rahnama

• Chair and Department of Oral Surgery, Medical University of Lublin, Karmelicka 7, 20-081 Lublin, Poland

author

Michal Lobacz

• Chair and Department of Oral Surgery, Medical University of Lublin, Karmelicka 7, 20-081 Lublin, Poland

author

Anna Szyszkowska

• Chair and Department of Oral Surgery, Medical University of Lublin, Karmelicka 7, 20-081 Lublin, Poland

author

Grzegorz Trybek

• Department of Oral Surgery, Pomeranian Medical University, al. Powstańców Wlkp. 72, 70-111 Szczecin, Poland

author

Maryla Kozicka-Czupkallo

• Chair and Department of Oral Surgery, Medical University of Lublin, Karmelicka 7, 20-081 Lublin, Poland

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Identifiers

DOI

10.2478/cipms-2014-0021