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2014 | 27 | 2 | 88-91

Article title

The influence of proteasome inhibitor on the expression of cardiomyocytes damage markers after incubation with doxorubicin

Content

Title variants

Languages of publication

EN

Abstracts

EN
The aim of the study was to verify the thesis that the cardiotoxic effects of doxorubicin are connected with activation of the ubiquitin - proteasome pathway followed by protein degradation. The expression of myocardial damage markers - fatty acid binding protein (H-FABP) and brain natriuretic peptide (BNP) was evaluated in rat fetal cardiomyocytes simultaneously treated with doxorubicin and the proteasome inhibitor - bortezomib. The level of H-FABP and BNP protein under the influence of doxorubicin was decreased below the detection threshold with unchanged (H-FABP) or elevated (BNP) mRNA expression level. Against the expectations, the inhibitor of proteasome did not abolish this effect. The observed abnormal expression of BNP and H-FABP protein after doxorubicin treatment makes their diagnostic significance in anthracycline cardiotoxicity questionable.

Keywords

EN

Publisher

Year

Volume

27

Issue

2

Pages

88-91

Physical description

Dates

published
1 - 6 - 2014
received
11 - 6 - 2014
accepted
13 - 6 - 2014
online
25 - 11 - 2014

Contributors

  • Independent Medical Biology Unit, Medical University of Lublin, Poland
  • Department of Histology and Embryology, Medical University of Lublin, Poland
  • Department of Pneumology Oncology and Allergology, Medical University of Lublin, Poland
  • Independent Medical Biology Unit, Medical University of Lublin, Poland
  • IMMUNIQ, Beata Solon-Gogol, Sasiedzka 1, 44-240 Zory, Poland
author
  • Regional Dental Clinic Independent Public Health Care, Lubartowska 58, Lublin, Poland
  • Department of Pediatric Pulmonology and Rheumatology, Medical University of Lublin, Poland
  • Independent Medical Biology Unit, Medical University of Lublin, Poland
  • Independent Medical Biology Unit, Medical University of Lublin, Poland

References

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  • 10. Liu J. et al.: A therapeutic dose of doxorubicin activates ubiquitinproteasome system-mediated proteolysis by acting on both the ubiquitination apparatus and proteasome. Am. J. Physiol. Heart Circ. Physiol., 295, H2541, 2008.
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  • 15. Sayed-Ahmad M. M. et al.: Protection by L-Carnitine Against the Inhibition of Gene Expression of Heart Fatty Acid Binding Protein by Chronic Administration of Doxorubicin. Journal of the Egyptian Nat. Cancer Inst., 4, 275, 2000.
  • 16. Sayed-Ahmed M. M. et al.: Inhibition of gene expression of heart fatty acid binding protein and organic cation/carnitine transporter in doxorubicin cardiomyopathic rat model. Eur. J. Pharmacol., 640, 143, 2010.[WoS]
  • 17. Sun Y. et al.: B-Type Natriuretic Peptide-Induced Cardioprotection against Reperfusion Is Associated with Attenaution of Mitochondrial Permeability Transition. Biol. Pharm. Bull, 32, 1545, 2009.
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Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.-psjd-doi-10_2478_cipms-2014-0020
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