One-pot synthesis of (R)-convolutamydine A
involving in situ chiral organocatalyst formation

• Authors: Shengwei Wei , Bernhard Schmid , Fliur Z. Macaev , Serghei N. Curlat , 1 , Andrei V. Malkov , Svetlana B. Tsogoeva
• Languages of publication: EN

Abstracts

EN

The application of a convenient one-pot synthetic
strategy, utilizing an in situ formed organocatalyst, to
the enantioselective synthesis of anti-leukaemia agent
(R)-convolutamydine A has been demonstrated.

Keywords

EN

chiral drug synthesis; organocatalysis; one-potreactions; amino alcohols; reduction; aldol reaction

• Publisher: De Gruyter Open
• Journal: Asymmetric Catalysis
• Year: 2015
• Volume: 2
• Issue: 1

Dates

online

12 - 1 - 2015

received

20 - 10 - 2014

accepted

29 - 10 - 2014

Contributors

author

Shengwei Wei

• Department of Chemistry and
  Pharmacy, Organic Chemistry Chair I and Interdisciplinary Center for
  Molecular Materials, University of Erlangen-Nürnberg, Henkestraße
  42, 91054, Erlangen, Germany

author

Bernhard Schmid

• Department of Chemistry and
  Pharmacy, Organic Chemistry Chair I and Interdisciplinary Center for
  Molecular Materials, University of Erlangen-Nürnberg, Henkestraße
  42, 91054, Erlangen, Germany

author

Fliur Z. Macaev

• Institute of Chemistry, Academy
  of Sciences of Moldova, Academy Str. 3, MD-2028 Chisinau,
  Moldova

author

Serghei N. Curlat

• Institute of Chemistry, Academy
  of Sciences of Moldova, Academy Str. 3, MD-2028 Chisinau,
  Moldova

author

1

• Department of Chemistry and
  Pharmacy, Organic Chemistry Chair I and Interdisciplinary Center for
  Molecular Materials, University of Erlangen-Nürnberg, Henkestraße
  42, 91054, Erlangen, Germany

author

Andrei V. Malkov

• Department of Chemistry, Loughborough University,
  Loughborough LE11 3TU, UK

author

Svetlana B. Tsogoeva

• Department of Chemistry and
  Pharmacy, Organic Chemistry Chair I and Interdisciplinary Center for
  Molecular Materials, University of Erlangen-Nürnberg, Henkestraße
  42, 91054, Erlangen, Germany

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Identifiers

DOI

10.2478/asorg-2014-0002