QSAR studies of 2-substituted 2,3-dihydro-1h-naphtho[1,8-de]-1,3,2-diazaphosphorine 2-oxides and sulphides

• Authors: A. Madhuritha , B. Kumar , T. Parthasarathy , V. Uma
• Languages of publication: EN

Abstracts

EN

A quantitative structure activity relationship (QSAR) study of 2-substituted 2,3-dihydro-1H-naphtho[1,8,de]-1,3,2-diazaphosphorine 2-oxides and sulphides (DND), examines the extent of the contribution by various physicochemical parameters with respect to their antimicrobial activity. Simple bivariant regression analysis, based on the least squares method, is applied in order to predict models. The predicted models reveal that the steric factor, MR, is the major contributor influencing antimicrobial activity. Bulky groups at the C-19 (C=0 group) position positively influence the potency of the compounds

Keywords

EN

QSAR; Regression analysis; 2-Substituted 2,3-Dihydro-1H-Naphtho[1,8-de]-1,3,2,-Diazophophorine 2-Oxides/Sulphides

• Publisher: De Gruyter Open
• Journal: Open Chemistry
• Year: 2004
• Volume: 2
• Issue: 4
• Pages: 696-702

Dates

published

1 - 12 - 2004

online

1 - 12 - 2004

Contributors

author

A. Madhuritha

• Department of Chemistry, Nizam College, Basheerbagh, Osmania University, 500001, Hyderabad, India

author

B. Kumar

• Department of Chemistry, Nizam College, Basheerbagh, Osmania University, 500001, Hyderabad, India

author

T. Parthasarathy

• Department of Chemistry, Nizam College, Basheerbagh, Osmania University, 500001, Hyderabad, India

author

V. Uma

• Department of Chemistry, Nizam College, Basheerbagh, Osmania University, 500001, Hyderabad, India

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Identifiers

DOI

10.2478/BF02482732