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Number of results

Journal

2004 | 2 | 4 | 696-702

Article title

QSAR studies of 2-substituted 2,3-dihydro-1h-naphtho[1,8-de]-1,3,2-diazaphosphorine 2-oxides and sulphides

Content

Title variants

Languages of publication

EN

Abstracts

EN
A quantitative structure activity relationship (QSAR) study of 2-substituted 2,3-dihydro-1H-naphtho[1,8,de]-1,3,2-diazaphosphorine 2-oxides and sulphides (DND), examines the extent of the contribution by various physicochemical parameters with respect to their antimicrobial activity. Simple bivariant regression analysis, based on the least squares method, is applied in order to predict models. The predicted models reveal that the steric factor, MR, is the major contributor influencing antimicrobial activity. Bulky groups at the C-19 (C=0 group) position positively influence the potency of the compounds

Publisher

Journal

Year

Volume

2

Issue

4

Pages

696-702

Physical description

Dates

published
1 - 12 - 2004
online
1 - 12 - 2004

Contributors

author
  • Department of Chemistry, Nizam College, Basheerbagh, Osmania University, 500001, Hyderabad, India
author
  • Department of Chemistry, Nizam College, Basheerbagh, Osmania University, 500001, Hyderabad, India
  • Department of Chemistry, Nizam College, Basheerbagh, Osmania University, 500001, Hyderabad, India
author
  • Department of Chemistry, Nizam College, Basheerbagh, Osmania University, 500001, Hyderabad, India

References

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Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.-psjd-doi-10_2478_BF02482732
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