Inclusion compounds of cystostatic active (C5H5)2VCl2 and (CH3C5H4)2VCl2 with α-, β- and γ-cyclodextrines: Synthesis, EPR study and microbiological behavior toward Escherichia coli

• Authors: Jaromír Vinklárek , Jan Honzíček , Jana Holubová
• Languages of publication: EN

Abstracts

EN

The inclusion of vanadocene dichloride (VDC) and 1,1′-dimethyl vanadocene dichloride (MeVDC) into cyclodextrines (α-CD, β-CD and γ-CD) was studied by EPR spectroscopy. It was found that VDC and MeVDC with β-CD and γ-CD form true inclusion compounds, but with α-CD, VDC and MeVDC gave only fine dispersion mixtures. The inclusion was validated by anisotropic EPR spectra of solid samples. In addition, the antimicrobial was validated by anisotropic EPR spectra of solid samples. In addition, the antimicrobial behavior (against E. coli) of each of the complexes was determined. It was established that not only did VDC and MeVDC cause elongation of E. coli, but also the new vanadocene inclusion complexes were effective in this regard.

Keywords

EN

EPR spectroscopy; vanadocene complexes; cyclodextrine; inclusion compounds; Escherichia coli; bent metallocene

• Publisher: De Gruyter Open
• Journal: Open Chemistry
• Year: 2005
• Volume: 3
• Issue: 1
• Pages: 72-81

Dates

published

1 - 3 - 2005

online

1 - 3 - 2005

Contributors

author

Jaromír Vinklárek

• Department of General and Inorganic Chemistry, University of Pardubice, nám. Čs. legií 565, 532 10, Pardubice, Czech Republic

author

Jan Honzíček

• Department of General and Inorganic Chemistry, University of Pardubice, nám. Čs. legií 565, 532 10, Pardubice, Czech Republic

author

Jana Holubová

• Department of General and Inorganic Chemistry, University of Pardubice, nám. Čs. legií 565, 532 10, Pardubice, Czech Republic

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Identifiers

DOI

10.2478/BF02476239