Impact of APEX Ile64val Gene Polymorphisms of DNA Repair Ber System on Modulation of the Risk of Colorectal Cancer in the Polish Population

• Authors: Jacek Kabziński , Ireneusz Majsterek , Michał Mik , Adam Dziki , Łukasz Dziki , Lucjan Maciejczak
• Languages of publication: EN

Abstracts

EN

Colorectal cancer (CRC) is one of the deadliest cancers which lie in the incidence of morbidity in second place. Intensive research is to determine and confirm the genetic basis of this disease, which is believed may have a direct relationship with the reduced efficiency of DNA repair systems. The aim of this study was to determine the effect of APEX gene polymorphism Ile64Val on increasing the risk of colorectal cancer in the Polish population. Material and methods. The blood samples collected from 150 patients diagnosed with colon cancer was used. The control group consisted of 150 healthy subjects. Genotyping was performed by TaqMan method. Results. The results indicate that genotype Ile Val is associated with an increased risk of colorectal cancer (OR 2.069; 95% CI 1,205-3,552; p = 0.008). Conclusions. Based on these results, we conclude that the APEX gene polymorphism Ile64Val may be associated with an increased risk of colorectal cancer.

Keywords

EN

colorectal cancer; polymorphisms; APEX; DNA repair

• Publisher: De Gruyter Open
• Journal: Polish Journal of Surgery
• Year: 2015
• Volume: 87
• Issue: 3
• Pages: 121-123

Dates

published

1 - 3 - 2015

online

3 - 7 - 2015

received

31 - 1 - 2015

Contributors

author

Jacek Kabziński

• Department of Clinical Chemistry and Biochemistry, Medical University in Łódź Kierownik: prof. dr hab. I. Majsterek

author

Ireneusz Majsterek

• Department of Clinical Chemistry and Biochemistry, Medical University in Łódź Kierownik: prof. dr hab. I. Majsterek

author

Michał Mik

• Department of General and Colorectal Surgery, Medical University in Łódź Kierownik: prof. dr hab. A. Dziki Department of General and Colorectal Surgery, Medical University in Łódź Kierownik: prof. dr hab. A. Dziki

author

Adam Dziki

• Department of General and Colorectal Surgery, Medical University in Łódź Kierownik: prof. dr hab. A. Dziki

author

Łukasz Dziki

• Department of General and Colorectal Surgery, Medical University in Łódź Kierownik: prof. dr hab. A. Dziki

author

Lucjan Maciejczak

• Department of Clinical Chemistry and Biochemistry, Medical University in Łódź Kierownik: prof. dr hab. I. Majsterek

References

• 1. Peltomäki P: Role of DNA mismatch repair defects in the pathogenesis of human cancer. J Clinic Oncology 2003; 21(6): 1174-79.
• 2. Chung DC , Rustgi AK: The Hereditary Nonpolyposis Colorectal Cancer Syndrome: Genetics and Clinical Implications (dhelix). Ann of Internal Med 2003; 138(7): 560-70.
• 3. Parker A, Gu Y, Mahoney W et al.: Human homolog of the MutY repair protein (hMYH) physically interacts with proteins involved in long patch DNA base excision repair. J Biolog Chemistry 2001; 276(8): 5547-55.
• 4. Vidal AE, Boiteux S, Hickson ID , Radicella JP: XRCC1 coordinates the initial and late stages of DNA abasic site repair through protein-protein interactions. The EM BO journal 2002; 20(22): 6530-39.
• 5. Goode EL , Ulrich CM , Potter JD : Polymorphisms in DNA repair genes and associations with cancer risk. Cancer Epidemiology Biomarkers & Prevention 2002; 11(12): 1513-30.
• 6. Chih-Ching Y, Fung-Chang S, Reiping T et al.: Polymorphisms of the XRCC1, XRCC3, & XPD genes, and colorectal cancer risk: a case-control study in Taiwan. BMC cancer 2005; 5(1): 12.
• 7. Moreno V, Gemignani F, Landi S et al.: Polymorphisms in genes of nucleotide and base excision repair: risk and prognosis of colorectal cancer. Clinical Cancer Research 2006; 12(7): 2101-08.
• 8. Kim, Jae-Il, Park Y-J, Kim Ki-H et al.: hOGG1 Ser326Cys polymorphism modifies the significance of the environmental risk factor for colon cancer.” World J Gastroenterol 2003; 9(5): 956-60.
• 9. Lo, Yen-Li, Jou, Yuh-Shan, Chang, Gee-Chen et al.: A polymorphism in the APE1 gene promoter is associated with lung cancer risk. Cancer Epidemiology Biomarkers & Prevention 2009; 18(1): 223-29.
• 10. Zienolddiny S, Campa D, Lind H et al.: Polymorphisms of DNA repair genes and risk of nonsmall cell lung cancer. Carcinogenesis 2006; 27(3): 560-67.
• 11. Kiyohara Chikako, Koichi Takayama, Yoichi Nakanishi: Association of genetic polymorphisms in the base excision repair pathway with lung cancer risk: a meta-analysis. Lung Cancer 2006; 54(3): 267-83.
• 12. Rayjean JH , Hall J, Brennan P, Boffetta P: Genetic polymorphisms in the base excision repair pathway and cancer risk: a HuGE review. American Journal of Epidemiology 2005; 162(10): 925-42.
• 13. Richardson PG, Sonneveld P, Schuster M et al.:: Extended follow-up of a phase 3 trial in relapsed multiple myeloma: final time to-event results of the APEX trial.” Blood 2007; 110(10): 3557-60.
• 14. De Laurentiis M, Arpino G, Massarelli E et al.: A meta-analysis on the interaction between HER-2 expression and response to endocrine treatment in advanced breast cancer. Clinical Cancer Research 2005; 11(13): 4741-48.

Identifiers

DOI

10.1515/pjs-2015-0030