Venous aneurysm complicating arteriovenous fistula access and matrix metalloproteinases

• Authors: Raffaele Serra , Lucia Butrico , Raffaele Grande , Girolamo Domenico Placida , Paolo Rubino , Ugo Francesco Settimio , Gennaro Quarto , Maurizio Amato , Ermenegildo Furino , Rita Compagna , Bruno Amato , Luca Gallelli , Stefano de Franciscis
• Languages of publication: EN

Abstracts

EN

Introduction: An arteriovenous fistula (AVF) for placed for hemodialysis may be burdened by one particular complication-the formation of a venous aneurysm. It has been shown that matrix metalloproteinases (MMPs) and neutrophil gelatinase-associated lipocalin (NGAL) could represent markers of disease in both venous and arterial vessels.Materials and methods: This case study reports a rare case of enormous venous aneurysm-correlated MMP and NGAL levels in a woman with an AVF.Results: Significantly higher levels of plasma MMP-1, MMP-8, MMP-9, and NGAL were detected in this patient during aneurysmal evaluation before the surgery; these levels significantly decreased 1, 3 and 6 months after surgery.Conclusion: MMP and NGAL levels could represent a marker of aneurysmal disease, and their plasma evaluation could help physicians to stratify the risk of complications in patients with an AVF.

Keywords

EN

arteriovenous fistula; matrix metalloproteinases; MMP; neutrophil gelatinase-associated lipocalin; NGAL; hemodialysis

• Publisher: De Gruyter Open
• Journal: Open Medicine
• Year: 2014
• Volume: 10
• Issue: 1

Dates

published

1 - 1 - 2015

online

17 - 12 - 2015

received

24 - 10 - 2015

accepted

4 - 11 - 2015

Contributors

author

Raffaele Serra

• Interuniversity Center of Phlebolymphology (CIFL). International Research and Educational Program in Clinical and Experimental Biotechnology. Headquarters: University Magna Græcia of Catanzaro, Viale Europa 88100 Catanzaro, Italy; Department of Medical and Surgical Sciences, University of Catanzaro, 88100, Italy

author

Lucia Butrico

• Department of Medical and Surgical Sciences, University of Catanzaro, 88100, Italy

author

Raffaele Grande

• Department of Medical and Surgical Sciences, University of Catanzaro, 88100, Italy

author

Girolamo Domenico Placida

• Department of Vascular Surgery, Pugliese-Ciaccio Hospital, Catanzaro, 88100, Italy

author

Paolo Rubino

• Department of Vascular Surgery, Pugliese-Ciaccio Hospital, Catanzaro, 88100, Italy

author

Ugo Francesco Settimio

• Department of Medical and Surgical Sciences, University of Catanzaro, 88100, Italy

author

Gennaro Quarto

• Department of Clinical Medicine and Surgery, University of Naples “Federico II”. 80100 Naples, Italy

author

Maurizio Amato

• Department of Clinical Medicine and Surgery, University of Naples “Federico II”. 80100 Naples, Italy

author

Ermenegildo Furino

• Department of Clinical Medicine and Surgery, University of Naples “Federico II”. 80100 Naples, Italy

author

Rita Compagna

• Interuniversity Center of Phlebolymphology (CIFL). International Research and Educational Program in Clinical and Experimental Biotechnology. Headquarters: University Magna Græcia of Catanzaro, Viale Europa 88100 Catanzaro, Italy

author

Bruno Amato

• Department of Clinical Medicine and Surgery, University of Naples “Federico II”. 80100 Naples, Italy

author

Luca Gallelli

• Department of Health Sciences, University of Catanzaro,88100, Catanzaro, Italy

author

Stefano de Franciscis

• Interuniversity Center of Phlebolymphology (CIFL). International Research and Educational Program in Clinical and Experimental Biotechnology. Headquarters: University Magna Græcia of Catanzaro, Viale Europa 88100 Catanzaro, Italy

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Identifiers

DOI

10.1515/med-2015-0088