Assessment of the feasibility of TACE combined with intratumoral injection of cisplatin in hepatocellular carcinoma

• Authors: Song Zhaomin , Liu Zifeng , Yin Chenghui , Yang Jiali , Peng Xun , Zhao Peili , Lang Xiaolin
• Languages of publication: EN

Abstracts

EN

The feasibility of transcatheter arterial chemoembolization (TACE) combined with intratumoral injection of cisplatin as treatment for hepatocellular carcinoma. 30 cases receiving TACE were denoted the TACE group, another 30 cases receiving TACE combined with an intratumoral multi-point injection of cisplatin were denoted the TACE/cisplatin group. Cases with partial remission/complete remission (PR/CR) were analyzed using 2 tests; alpha fetoprotein (AFP), aspartate amino transferase (AST), total bilirubin (TBIL), erythrocyte, and platelet levels were detected and the differences between two groups were analyzed using the Student’s t-test; cases with complications, including intrahepatic metastasis (IM), upper gastrointestinal bleeding (UGB), and liver failure were also counted. The correlation of clinical parameters with PR/CR was analyzed using multifactorial correlation analysis. Cases with PR/CR in the TACE/cisplatin group were significantly more than in TACE group, accompanied by significant declination in FAP. There were no significant differences of AST, ALT, TBIL, blood urea nitrogen (BUN), white blood cells (WBC), red blood cells (RBC), and platelets (PLT) between two groups; 3 cases with IM, one case with UGB and one case with LF were found in the TACE group, but only 1 case with IM was found in the TACE/cisplatin group. In addition, tumor stage was correlated with PR/CR. We concluded that TACE combined with intratumoral injection of cisplatin was more effective than TACE, and with fewer complications and side effects.

Keywords

EN

Transcatheter arterial chemoembolization (TACE); intratumoral injection of cisplatin; alpha fetoprotein (AFP)

• Publisher: De Gruyter Open
• Journal: Open Medicine
• Year: 2014
• Volume: 10
• Issue: 1

Dates

published

1 - 1 - 2015

received

10 - 7 - 2015

online

17 - 12 - 2015

accepted

30 - 9 - 2015

Contributors

author

Song Zhaomin

• Third Hospital of Qinhuangdao city, China

author

Liu Zifeng

• Third Hospital of Qinhuangdao city, China

author

Yin Chenghui

• Third Hospital of Qinhuangdao city, China

author

Yang Jiali

• The Shandong province Zibo City Qidu hospital, Qinhuangdao City Third Hospital Road, Haigang district the founding of Hebei city of Qinhuangdao province No. 222, zip code 066000 China, Tel; 15864477727

author

Peng Xun

• Third Hospital of Qinhuangdao city, China

author

Zhao Peili

• Third Hospital of Qinhuangdao city, China

author

Lang Xiaolin

• Third Hospital of Qinhuangdao city, China

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Identifiers

DOI

10.1515/med-2015-0075