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Journal

2014 | 10 | 1 |

Article title

Profile of adult acute cholinesterase inhibitors
substances poisoning – a 30 years analysis

Content

Title variants

Languages of publication

EN

Abstracts

EN
Objectives: The objective of this study was to
assess the pattern and outcome of acute cholinesterase
inhibitors substances (CIS) poisoning cases, in a
cohort from a regional tertiary care hospital. Methods:
cases admitted in the Toxicology Clinic of “Sf. Spiridon”
Emergency Clinic Hospital Iasi, Romania between 1983
and 2013 were studied. Results: a total number of 606
patients were included. The reason for exposures was
intentional in 70% of cases and the commonest route of
poisoning was oral in 92.2%. The highest percent of cases
was females (56.4), the age group 20-29 (25.4%) and the
majority (66.7%) coming from rural areas, 28.2% being
agricultural workers. 36.6% of cases were severe clinical
forms. Overall mortality rates were 3.8%, more than half
of the death patients (65.2%) had concomitant alcohol
intake. It was a significant statistical association between
decrease level of serum cholinesterase on admittance and
severe forms (p 0.000) and between survival and deaths
groups (p 0.000). The pattern of poisoning described by
our retrospective study suggests that CIS poisoning are
mainly preventable. The main effective goals for prevention
are restriction in free accessibility to toxic pesticides,
together with sustained efforts in education concerning
the life-threatening danger of pesticide poisoning.

Keywords

Publisher

Journal

Year

Volume

10

Issue

1

Physical description

Dates

received
18 - 9 - 2014
accepted
31 - 3 - 2015
online
8 - 5 - 2015

Contributors

  • „Sf. Spiridon” Emergency Clinic Hospital, Internal Medicine
    and Toxicology Department, School of Medicine „Gr. T. Popa”
    University of Medicine and Pharmacy, Iasi, Romania
  • „Sf. Spiridon” Emergency Clinic Hospital, Internal Medicine
    and Toxicology Department, School of Medicine „Gr. T. Popa”
    University of Medicine and Pharmacy, Iasi, Romania
author
  • Pharmacology – Toxicology Department,
    Faculty of Medicine, „Gr. T. Popa” University of Medicine
    and Pharmacy, Iasi, Romania
  • „Sf. Spiridon” Emergency Clinic Hospital, Internal Medicine
    and Toxicology Department, School of Medicine „Gr. T. Popa”
    University of Medicine and Pharmacy, Iasi, Romania
  • „Sf. Spiridon” Emergency Clinic Hospital, Internal Medicine
    and Toxicology Department, School of Medicine „Gr. T. Popa”
    University of Medicine and Pharmacy, Iasi, Romania
  • Pharmacology – Toxicology Department,
    Faculty of Medicine, „Gr. T. Popa” University of Medicine
    and Pharmacy, Iasi, Romania
  • Physiopathology Department, Faculty of Medicine,
    „Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania
  • „Sf. Spiridon” Emergency Clinic Hospital, Internal Medicine
    and Toxicology Department, School of Medicine „Gr. T. Popa”
    University of Medicine and Pharmacy, Iasi, Romania
author
  • „Sf. Spiridon” Emergency Clinic Hospital, Internal Medicine
    and Toxicology Department, School of Medicine „Gr. T. Popa”
    University of Medicine and Pharmacy, Iasi, Romania

References

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Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.-psjd-doi-10_1515_med-2015-0041
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