Correlation between SNPs in CDH1 and gastric
cancer in Chinese population

• Authors: Yijin Lin , Jintao Yuan , Lihui Wang , Lan Wang , Yunjia Ma , Yuhua Wang , Jianhong Chen , Hong Zhao
• Languages of publication: EN

Abstracts

EN

Background. Many recent studies revealed that
the single nucleotide polymorphisms have considerable
effects on the susceptibility of cancer, such as prostate
cancer, lung cancer and gastric cancer. The E-cadherin, a
calcium-dependent transmembrane glycoprotein encoded
by CDH1 gene, is critical for epithelial construction, intercellular
adhesion and cell migration. Some associations
have been reported between single nucleotide polymorphisms
and gastric cancer in the Chinese population.
Objective. To investigate whether the single nucleotide
polymorphism in CDH1 gene is associated with the susceptibility
of gastric cancer in the Chinese population.
Material and methods. The genotypes of 5 known single
nucleotide polymorphisms (rs33935154, rs121964871,
rs121964874, rs121964875, rs121964876) were determined in 359 gastric cancer patients and 368 healthy controls.
High resolution melting curve detection and sequencing
analysis were used in the present study. Results. There
is a statistical significance in the rs121964871 C>G polymorphism
between gastric cancer patients and healthy
controls (OR=1.769, 95%CI: 1.051-2.976). Elderly male individuals
(>50 years of age) carrying this risk factor may
be more susceptible to gastric cancer. Conclusions. The
results indicated that the rs121964871 C>G polymorphism
is associated with the susceptibility of gastric cancer in
the Chinese population, with some age and sex-dependent
tendencies observed.

Keywords

EN

Single nucleotide polymorphism; Gastric cancer; CDH1 gene

• Publisher: De Gruyter Open
• Journal: Open Medicine
• Year: 2014
• Volume: 10
• Issue: 1

Dates

published

1 - 1 - 2015

received

20 - 7 - 2014

accepted

28 - 8 - 2014

online

3 - 11 - 2014

Contributors

author

Yijin Lin

• Danyang People’s Hospital of
  Jiangsu Province, Danyang, China, Danyang Hospital affiliated to
  Nantong University, Danyang, Jiangsu 212300, China

author

Jintao Yuan

• Danyang People’s Hospital of
  Jiangsu Province, Danyang, China, Danyang Hospital affiliated to
  Nantong University, Danyang, Jiangsu 212300, China

author

Lihui Wang

• Danyang People’s Hospital of
  Jiangsu Province, Danyang, China, Danyang Hospital affiliated to
  Nantong University, Danyang, Jiangsu 212300, China

author

Lan Wang

• Danyang Blood Center of Jiangsu Province, Danyang,
  Jiangsu 212300, China

author

Yunjia Ma

• Danyang People’s Hospital of
  Jiangsu Province, Danyang, China, Danyang Hospital affiliated to
  Nantong University, Danyang, Jiangsu 212300, China

author

Yuhua Wang

• Danyang People’s Hospital of
  Jiangsu Province, Danyang, China, Danyang Hospital affiliated to
  Nantong University, Danyang, Jiangsu 212300, China

author

Jianhong Chen

• Danyang People’s Hospital of
  Jiangsu Province, Danyang, China, Danyang Hospital affiliated to
  Nantong University, Danyang, Jiangsu 212300, China

author

Hong Zhao

• Danyang People’s Hospital of
  Jiangsu Province, Danyang, China, Danyang Hospital affiliated to
  Nantong University, Danyang, Jiangsu 212300, China

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Identifiers

DOI

10.1515/med-2015-0007