Cost comparison of treating chronic hepatitis C genotype one with pegylated interferons in Ukraine

• Authors: Olena Mandrik , Saskia Knies , Оlha Golubovska , Oleksandr Duda , Larisa Dudar , Sergiy Fedorchenko , Оlha Zaliska , J. L. (Hans) Severens
• Languages of publication: EN

Abstracts

EN

Based on the pivotal trial showing no clinicallyrelevant
differences between pegylated interferon α-2b
(Peg-α-2b) and α-2a (Peg-α-2a) combined with ribavirin
for treatment of chronic hepatitis C virus (HCV) genotype
1 infection in Ukraine, a cost-minimization analysis was
performed using a 1 year time horizon and both a health
care and patients’ perspective. A decision tree reflects
treatment pathways. Drug costs were based on drug labeling
and adjusted to the average body mass in Ukraine.
Subgroup analysis was applied to deal with heterogeneity
of patient’s weight causing dose changes. A break-even
price of Peg-α-2a and Peg-α-2b (based on the average dose)
was calculated. Univariate sensitivity analyses and probabilistic
sensitivity analysis were carried out to reflect
decision uncertainty. For an average body weight, total
medical costs per patient differ from US$9220 for Peg-α-2b
to US$9513 for Peg-α-2a from a health care perspective, and
from US$15,212 to US$15,696 from a patients’ perspective. Sensitivity analyses show these results are robust. With
average body weight, the break-even price of Peg-α-2b may
be 7.3% higher than Peg-α-2a to have similar total costs.

Keywords

EN

Cost minimization; Pegylated interferon; Chronic hepatitis C; Ukraine

• Publisher: De Gruyter Open
• Journal: Open Medicine
• Year: 2014
• Volume: 10
• Issue: 1

Dates

published

1 - 1 - 2015

received

28 - 4 - 2013

accepted

8 - 1 - 2014

online

8 - 10 - 2014

Contributors

author

Olena Mandrik

• Institute of Health Policy &
  Management, Erasmus University Rotterdam, P.O. Box 1738, 3000
  DR Rotterdam, the Netherlands

author

Saskia Knies

• Dutch Health Care Insurance Board, PO Box 320.,
  1110 AH Diemen, the Netherlands; Institute of Health Policy & Management,
  Erasmus University Rotterdam, P.O. Box 1738, 3000 DR
  Rotterdam, the Netherlands

author

Оlha Golubovska

• O. Bogomolets National Medical University, Shevchenko
  av. 13., 01601 Kyiv, Ukraine

author

Oleksandr Duda

• P.L. Shupyk National Medical Academy of Postgraduate
  Education, Dorohozhyts’ka str. 9., 04112 Kyiv, Ukraine

author

Larisa Dudar

• O. Bogomolets National Medical University, Shevchenko
  av. 13., 01601 Kyiv, Ukraine

author

Sergiy Fedorchenko

• L. Gromashevskyi Institute of Epidemiology
  and Infectious Diseases, Amosova str. 5., 03038 Kyiv, Ukraine

author

Оlha Zaliska

• Danylo Halytsky Lviv National Medical University,
  Pekarska St. 69, 79010 Lviv, Ukraine

author

J. L. (Hans) Severens

• Institute of Health Policy & Management, Erasmus
  University Rotterdam, P.O. Box 1738, 3000 DR Rotterdam, the
  Netherlands, Institute of Medical Technology Assessment (iMTA),
  Erasmus University Rotterdam, P.O. Box 1738, 3000 DR Rotterdam,
  the Netherlands

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Identifiers

DOI

10.1515/med-2015-0006