Effects of Regular Recreational Exercise Training on Serum ANGPTL3-Like Protein and Lipid Profile in Young Healthy Adults

• Authors: Ewelina Smol , Barbara Kłapcińska , Katarzyna Kempa , Artur Fredyk , Andrzej Małecki
• Languages of publication: EN

Abstracts

EN

Evidence of the role of ANGPTL3, a liver-secreted glycoprotein, in serum lipid turnover, led us to hypothesize that this protein may be involved in modification of the lipid profile induced by exercise-training. Given the lack of data regarding this issue, the main goal of the present study was to investigate the effects of regular participation in a recreational physical activity program on serum ANGPTL3 and selected lipid profile measures in young, apparently healthy female and male adults. We compared serum ANGPTL3, lipid profile measures, common lipid ratios, the Atherogenic Index of Plasma (AIP) and glucose in fasting blood samples derived from 22 active physical education students including active females (AF, N=6) and males (AM, N=16) with samples from 28 relatively sedentary agematched peers, including female (SF, N=9) and male (SM, N=19) individuals not involved in any regular physical conditioning program. Despite high inter-individual variability of serum ANGPTL3, there was a general tendency toward higher serum ANGPTL3 and HDL-C in women compared to men, but without significant differences related to their physical activity status. Based on both routine lipid profile measures and lipid ratios, all participants had normal lipid profiles, normal glycemia, as well as favorable anthropometric indices not suggesting increased cardiometabolic risk. However, lower levels of the TG/HDL-C ratio and AIP in physically active compared to relatively sedentary participants, reflecting the predominance of large, buoyant LDL particles, strongly support the view of beneficial healthpromoting effects of regular participation in recreational sport activities.

Keywords

EN

angiopoietin-like protein 3; serum HDL-cholesterol; recreational physical activity

• Publisher: De Gruyter Open
• Journal: Journal of Human Kinetics
• Year: 2015
• Volume: 49
• Issue: 1
• Pages: 109-118

Dates

published

1 - 12 - 2015

accepted

1 - 12 - 2015

online

30 - 12 - 2015

Contributors

author

Ewelina Smol

• Department of Physiological and Medical Sciences, Jerzy Kukuczka Academy of Physical Education, 72A Mikołowska St., 40-065 Katowice, Poland

author

Barbara Kłapcińska

• Department of Physiological and Medical Sciences, The Jerzy Kukuczka Academy of Physical Education in Katowice, Poland

author

Katarzyna Kempa

• Department of Physiological and Medical Sciences, The Jerzy Kukuczka Academy of Physical Education in Katowice, Poland

author

Artur Fredyk

• Department of Individual Sports, The Jerzy Kukuczka Academy of Physical Education in Katowice, Poland

author

Andrzej Małecki

• Department of Physiotherapy in Neurological and Musculoskeletal Disorders, The Jerzy Kukuczka Academy of Physical, Education in Katowice, Poland

References

• Deep SS, Zambon A, Carr MC, Ayyobi AF, Brunzell JD. Hepatic lipase and dyslipidemia: interactions among genetic variants, obesity, gender, and diet. J Lipid Res, 2003; 44: 1279-1286[Crossref]
• Després JP, Arsenault BJ, Côté M, Cartier A, Lemieux I. Abdominal obesity: the cholesterol of the 21 st century? Can J Cardiol, 2008; 24 (suppl D): 7D-12D
• Dobiášová M, Frohlich J, Sedová M, Cheung MC, Brown BG. Cholesterol esterification and atherogenic index of plasma correlate with lipoprotein size and findings on coronary angiography. J Lipid Res, 2011; 52(3): 566-71[Crossref][WoS]
• Durstine JL, Grandjean PW, Davis PG, Ferguson MA, Alderson NL, DuBose KD. Blood lipid and lipoprotein adaptations to exercise. a quantitative analysis. Sports Med, 2001; 31(15): 1033-1062[Crossref]
• Fujimoto K, Koishi R, Shimizugawa I, Ando Y. Angptl3-null mice show lower plasma lipid concentrations by enhanced lipoprotein lipase activity. Exp Anim, 2006; 55(1): 27-34[Crossref]
• Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Blaha MJ, Dai S, Ford ES, Fox CS, Franco S, Fullerton HJ, Gillespie C, Hailpern SM, Heit JA, Howard VJ, Huffman MD, Judd SE, Kissela BM, Kittner SJ, Lackland DT, Lichtman JH, Lisabeth LD, Mackey RH, Magid DJ, Marcus GM, Marelli A, Matchar DB, McGuire DK, Mohler ER 3rd, Moy CS, Mussolino ME, Neumar RW, Nichol G, Pandey DK, Paynter NP, Reeves MJ, Sorlie PD, Stein J, Towfighi A, Turan TN, Virani SS, Wong ND, Woo D, Turner MB; American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics - 2014 update a report from the American Heart Association. Circulation, 2014; 129(3): e28-e292
• Grundy SM, Cleeman JI, Merz CN, Brewer HB Jr, Clark LT, Hunninghake DB, Pasternak RC, Smith SC Jr, Stone NJ; Coordinating Committee of the National Cholesterol Education Program. Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines. Arterioscler Thromb Vasc Biol, 2004; 24(8): e149-61[Crossref]
• Halverstadt A, Phares DA, Ferreli RE, Wilund KR, Goldberg AP, Hagberg JM. High-density lipoproteincholesterol, its subfractions, and responses to exercise training are dependent on endothelial lipase genotype. Metabolism, 2003; 52(11): 1505-1511[Crossref]
• Hanak V, Munoz J, Teague J, Stanley A Jr, Bittner V. Accuracy of the Triglyceride to High-Density Lipoprotein Cholesterol Ratio for Prediction of the Low-Density Lipoprotein Phenotype B. Am J Cardiol, 2004; 15(94): 219-222[Crossref]
• Hatsuda S, Shoji T, Shinohara K, Kimoto E, Mori K, Fukumoto S, Koyama H, Emoto M, Nishizawa Y. Association between plasma angiopoietin-like protein 3 and arterial wall thickness in healthy subjects. J Vasc Res, 2007; 44(1): 61-66[WoS][Crossref]
• Ingelsson E, Schaefer EJ, Contois JH, McNamara JR, Sullivan L, Keyes MJ, Pencina MJ, Schoonmaker C, Wilson PW, D’Agostino RB, Vasan RS SV. Clinical utility of different lipid measures for prediction of coronary heart disease in men and women. JAMA, 2007; 298(7): 776-785[WoS]
• Jaye M, Krawiec J. Endothelial lipase and HDL metabolism. Curr Opin Lipidol, 2004; 15(2): 183-189[Crossref]
• Kłapcińska B, Kroemeke A, Tataruch M, Tataruch R, Szołtysek-Bołdys I, Derejczyk J, Kimsa E, Iskra J. Effects of long-term regular exercise on cognitive function, lipid profile and atherogenic biomarkers in middle-aged men. J Hum Kinet, 2008; 20: 89-98[Crossref]
• Leaf DA. The effect of physical exercise on reverse cholesterol transport. Metabolism, 2003; 52(8): 950-957[Crossref]
• Legry V, Bokor S, Cottel D, Beghin L, Catasta G, Nagy E, Gonzalez-Gross M, Spinneker A, Stehle P, Molnár D, Moreno LA, Amouyel P, Dallongeville J, Meirhaeghe A. Associations between common genetic polymorphisms in angiopoietin-like proteins 3 and 4 and lipid metabolism and adiposity in European adolescents and adults. J Clin Endocrinol Metab, 2009; 94(12): 5070-7[WoS][Crossref]
• Mattijssen F, Kersten S. Regulation of triglyceride metabolism by Angiopoietin-like proteins. Biochim Biophys Acta, 2012; 1821: 782-789
• Mehta N, Qamar A, Qu L, Quasim AN, Mehta NN, Reilly MP, Rader DI. Differential association of plasma aniopoietin-like proteins 3 and 4 with lipid and metabolic traits. Arterioscler Thromb Vasc Biol, 2014; 34: 1057-1063[Crossref][WoS]
• Miida T, Seino U, Miyazaki O, Hanyu O, Hirayama S, Saito T, Ishikawa Y, Akamatsu S, Nakano T, Nakajima K, Okazaki M. Okada M. Probucol markedly reduces HDL phospholipids and elevated prebeta1-HDL without delayed conversion into alphaα-migrating HDL: putative role of angiopoietin-like protein 3 in probucol-induced HDL remodeling. Atherosclerosis, 2008; 200(2): 329-335[WoS]
• Moon HD, Nakajima, K, Kamiyama, K, Takanashi K, Sakurabayashi I, Nagamine T. Higher frequency of abnormal serum angiopoietin-like protein 3 than abnormal cholesteryl ester transfer protein in Japanese hyperalphalipoproteinemic subjects. Clin Chim Acta, 2008; 398(1-2): 99-104[WoS]
• Nakajima K, Kobayashi J, Mabuchi H, Nakano T, Tokita Y, Nagamine T, Imamura S, Ai M, Otokozawa S, Schaefer EF. Association of angiopoietin-like protein 3 with hepatic triglyceride lipase and lipoprotein lipase activities in human plasma. Ann Clin Biochem, 2010; 47: 423-31[WoS][Crossref]
• Popovic M, Puchner S, Endler G, Foraschik C, Minar E, Bucek RA. The effects of endurance and recreational exercise on subclinical evidence of atherosclerosis in young adults. Am J Med Sci, 2010; 339(4): 332-6[WoS]
• Rašlová K, Dobiášová M, Hubáček JA, Bencová D, Siváková D, Danková Z, Franeková J, Jabor A, Gašparovič J, Vohnout B. Association of metabolic and genetic factors with cholesterol esterification rate in HDL plasma and Atherogenic Index of Plasma in a 40 years old Slovak population. Physiol Res, 2011; 60(5): 785-795
• Robciuc MR, Maranghi M, Lahikainen A, Rader D, Bendsadoun A, Öörni K, Metso J, Minicocci I, Ciociola E, Ceci F, Montali A, Arca M, Ehnholm C, Jauhiainen M. Angptl3 deficiency is associated with increased insulin sensitivity lipoprotein lipase activity, and decreased serum free fatty acids. Arterioscler Thromb Vasc Biol, 2013; 33: 1706-1713[WoS][Crossref]
• Robciuc MR, Tahvanainen E, Jauhiainen M, Ehnholm Ch. Quantitation of serum angiopoietin-like proteins 3 and 4 in Finnish population sample. J Lipid Res, 2010; 51 (4): 824-831[Crossref][WoS]
• Scheers T, Philippaerts R, Van Langendonck L, Duquet W, Duvigneaud N, Matton L, Thomis M, Wijndaele K, Lefevre J. Lipid profile in men and women with different levels of sports participation and physical activity. Public Health Nutrit, 2008; 11(11): 1098-1106
• Seip RL, Angelopoulos TJ, Semenkovich CF. Exercise induces human lipoprotein lipase gene expression in skeletal muscle but not adipose tissue. Am J Physiol, 1995; 268(2): E 229-236
• Shimamura M, Matsuda M, Yasumo H, Okazaki M, Fujimoto K, Kono K, Shimizugawa T, Ando Y, Koishi R, Kohama T, Sakai N, Kotani K, Komuro R, Ishida T, Hirata K, Yamashita S, Furukawa H, Shimomura I. Angiopoietin-like protein 3 regulates HDL cholesterol through suppression of endothelial lipase. Arteriooscler Thromb Vasc Biol, 2007; 27: 366-372[Crossref]
• Shoji T, Hatsuda S, Tsuchikura S, Kimoto E, Kakiya R, Tahara H, Koyama H, Emoto M, Tabata T, Nishizawa Y. Plasma angiopoietin-like protein 3 (anptl3) concentration is associated with uremic dyslipidemia. Atherosclerosis, 2009; 207(2): 579-84[WoS]
• Stejskal D, Karpišek M, Humeňanská V, Solichová P, Stejskal P. Angiopoietin-like protein 3: development, analytical characterization, and clinical testing of a new Elisa. Gen Physiol Biophys, 2007; 26: 230-233
• Tambalis K, Panagiotakos DB, Kavouras SA, Sidossis LS. Responses of blood lipids to aerobic, resistance, and combined aerobic with resistance exercise training: a systematic review of current evidence.Angiology, 2009; 60(5): 614-32 [Crossref][WoS]

Identifiers

DOI

10.1515/hukin-2015-0113