Genesis of ER Stress in Huntington’s Disease

• Authors: Marina Shenkman , Hagit Eiger , Gerardo Z. Lederkremer
• Languages of publication: EN

Abstracts

EN

Recent research has identified ER stress as a
major mechanism implicated in cytotoxicity in many
neurodegenerative diseases, among them Huntington’s
disease. This genetic disorder is of late-onset, progressive
and fatal, affecting cognition and movement. There is
presently no cure nor any effective therapy for the disease.
This review focuses on recent findings that shed light on
the mechanisms of the advent and development of ER
stress in Huntington’s disease and on its implications,
highlighting possible therapeutic avenues that are being
or could be explored.

Keywords

EN

Huntington; neurodegenerative disease; conformational disease; protein misfolding; proteinaggregation; unfolded protein response; ER-associateddegradation

• Publisher: De Gruyter Open
• Journal: Endoplasmic Reticulum Stress in Diseases
• Year: 2015
• Volume: 2
• Issue: 1

Dates

accepted

15 - 7 - 2015

online

28 - 8 - 2015

received

8 - 6 - 2015

Contributors

author

Marina Shenkman

• Department of Cell Research
  and Immunology, George Wise Faculty of Life sciences, Tel Aviv
  University, Tel Aviv 69978, Israel
• Sagol School of Neuroscience, Tel
  Aviv University, Tel Aviv 69978, Israel

author

Hagit Eiger

• Department of Cell Research
  and Immunology, George Wise Faculty of Life sciences, Tel Aviv
  University, Tel Aviv 69978, Israel
• Sagol School of Neuroscience, Tel
  Aviv University, Tel Aviv 69978, Israel

author

Gerardo Z. Lederkremer

• Department of Cell Research
  and Immunology, George Wise Faculty of Life sciences, Tel Aviv
  University, Tel Aviv 69978, Israel
• Sagol School of Neuroscience, Tel
  Aviv University, Tel Aviv 69978, Israel

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Identifiers

DOI

10.1515/ersc-2015-0007