The unfolded protein response, inflammation,
oscillators, and disease: a systems biology
approach

• Authors: Rafael Rangel-Aldao
• Languages of publication: EN

Abstracts

EN

Non-communicable diseases (NCDs) such as
cardiovascular disease, cancers, diabetes and obesity are
responsible for about two thirds of mortality worldwide,
and all of these ailments share a common low-intensity
systemic chronic inflammation, endoplasmic reticulum
stress (ER stress), and the ensuing Unfolded Protein
Response (UPR). These adaptive mechanisms are also
responsible for significant metabolic changes that feedback
with the central clock of the suprachiasmatic nucleus
(SCN) of the hypothalamus, as well as with oscillators
of peripheral tissues. In this review we attempt to use a
systems biology approach to explore such interactions as
a whole; to answer two fundamental questions: (1) how
dependent are these adaptive responses and subsequent
events leading to NCD with their state of synchrony with
the SCN and peripheral oscillators? And, (2) How could
modifiers of the activity of SCN for instance, food intake,
exercise, and drugs, be potentially used to modulate
systemic inflammation and ER stress to ameliorate or even
prevent NCDs?

Keywords

EN

Systems biology; inflammation; circadian; oscillators; metabolism; communicable diseases; UPR; stress

• Publisher: De Gruyter Open
• Journal: Endoplasmic Reticulum Stress in Diseases
• Year: 2015
• Volume: 2
• Issue: 1

Dates

accepted

2 - 1 - 2015

received

21 - 10 - 2014

online

26 - 2 - 2015

Contributors

author

Rafael Rangel-Aldao

• Department of
  Technology of Biological Processes and Group of Digital Science,
  Simon Bolivar University, Caracas, 1083, Venezuela

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Identifiers

DOI

10.1515/ersc-2015-0003