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2014 | 27 | 4 | 263-266

Article title

The hepatoprotective activity of the herbal preparation Salivin against carbon tetrachloride (Ccl4) induced hepatotoxicity in rabbits

Content

Title variants

Languages of publication

EN

Abstracts

EN
Recently, a trend has developed towards employing certain herbal medicines to manage hepatotoxicity. The present study is that of an assessment of the efficacy of a herbal preparation of Salivin (HPS), a combination of the herbs of Saussurea amara (L.)DC., Salsola collina Pall., Achillea asiatica Serg. and rhizomes of Glycyrrhiza uralensis Fisch, in rabbit models, against CCl4-induced hepatic damage. In so doing, an extract of HPS (200 mg/kg body weight/day), along with reference control tablets of Carsil (Silymarin 35 mg) (250 mg/kg body weight/day) (which is known for its hepatoprotective effects) were administered, along with the standard diet. The experimental group of rabbits received HPS orally for 28 days, which resulted in a decrease in blood enzymes (aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase), compared to the control. Evidenced by biochemical and histopathological studies, it is concluded that the polyherbal formulation HPS showed hepatoprotective activity against induced CCl4 hepatotoxicity in rabbits.

Publisher

Year

Volume

27

Issue

4

Pages

263-266

Physical description

Dates

published
1 - 12 - 2014
accepted
12 - 9 - 2014
received
22 - 8 - 2014
online
3 - 3 - 2015

Contributors

  • School of Pharmacy and Biomedicine, Mongolian National University of Medical Sciences
  • School of Pharmacy and Biomedicine, Mongolian National University of Medical Sciences
  • New Medicine” Medical Institute of Mongolia
  • New Medicine” Medical Institute of Mongolia
  • School of Pharmacy and Biomedicine, Mongolian National University of Medical Sciences
  • School of Pharmacy and Biomedicine, Mongolian National University of Medical Sciences
  • School of Pharmacy and Biomedicine, Mongolian National University of Medical Sciences
  • New Medicine” Medical Institute of Mongolia

References

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  • 8. Nikiforov S B, Semenov AA, Syrchina AI. Effect of the aqueous extract of the aboveground parts of Salsola collina Pall on the distribution of cholesterol in blood serum lipoprotein fractions, in rabbits with experimental cholelithiasis. Khimiko-Farmatsevticheskii Zhurnal. 2012; 36 (10): 27-28.
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  • 16. Shim SB, Kim NJ, Kim DH. Beta-glucuronidase inhibitory activity and hepatoprotective effect of 18 beta-glycyrrhetinic acid, from the rhizomes of Glycyrrhiza uralensis. Planta Med. 2000; 66: 40-43.[Crossref]
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Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.-psjd-doi-10_1515_cipms-2015-0030
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