Multiprobiotic therapy from childhood prevents the development of nonalcoholic fatty liver disease in adult monosodium glutamate-induced obese rats

• Authors: Maryana Kondro , Nazarii Kobyliak , Oleksandr Virchenko , Tetyana Falalyeyeva , Tetyana Beregova , Petro Bodnar
• Languages of publication: EN

Abstracts

EN

Considering the association between microflora and obesity, and the significantly higher prevalence of non-alcoholic fatty liver disease (NAFLD) in obese people, the aim of our study was to investigate the preventive effect of multiprobiotics on the monosodium glutamate (MSG) induced NAFLD model, in rats. The work was carried out on 60 rats placed into three groups: the Control group, the MSG-group and the MSG-probiotic group. The MSG-group and the MSG-probiotic group were injected with 4 mg/g of MSG subcutaneously neonatally on the 2nd-10th days of life. The MSG-probiotic rats were also treated with 140 mg/kg of multiprobiotic “Symbiter” from the 4th week of life. In the 4-month-old rats, biochemical and morphological changes in liver were assessed, and steatosis was confirmed by the NAFLD activity score (NAS). Our results reveal that the multiprobiotic lowered total NAS, the degree of steatosis and the liver lobular inflammation caused by MSG. It also brought about decreased liver total lipids and triglycerids content, as well as decreased visceral adipose tissue mass. However, there was no difference in the liver serum biochemical indicators between all experimental groups. The obtained data does suggest the efficacy of probiotics in the prevention of NAFLD.

Keywords

EN

monosodium glutamate; non-alcoholic fatty liver disease; multiprobiotic

• Publisher: De Gruyter Open
• Journal: Current Issues in Pharmacy and Medical Sciences
• Year: 2014
• Volume: 27
• Issue: 4
• Pages: 243-245

Dates

published

1 - 12 - 2014

accepted

12 - 12 - 2014

online

3 - 3 - 2015

received

7 - 11 - 2014

Contributors

author

Maryana Kondro

• Danylo Halytsky Lviv National Medical University, Ukraine

author

Nazarii Kobyliak

• Bogomolets National Medical University, Ukraine

author

Oleksandr Virchenko

• Taras Shevchenko National University of Kyiv, Volodymyrska 64/13, Kyiv, 01601, Ukraine

author

Tetyana Falalyeyeva

• Taras Shevchenko National University of Kyiv, Volodymyrska 64/13, Kyiv, 01601, Ukraine

author

Tetyana Beregova

• Taras Shevchenko National University of Kyiv, Volodymyrska 64/13, Kyiv, 01601, Ukraine

author

Petro Bodnar

• Bogomolets National Medical University, Ukraine

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Identifiers

DOI

10.1515/cipms-2015-0025