Investigation of the hepatoprotective properties of “Phytovenol” capsules on the model of medicamentous hepatitis in rats

• Authors: Oleg Gerush , Olena Lenytska , Larysa Yakovleva , Liudmyla Gladkova , Igor Gerush
• Languages of publication: EN

Abstracts

EN

This scientific paper is an investigation of the pharmacological activity of the new medical preparation “Phytovenol” (capsules in the dose of 150 mg/kg) on the pattern of hepatitis in rats induced by paracetamol administration. The authors of the article, for the first time under experimental conditions, detected a hepatoprotective effect that was brought about by “Phytovenol” capsule administration. This is realized due to the antioxidant, antitoxic and anticytolytic activity of the examined medicine. The study found that its efficacy is not lower than the classical hepatoprotector - “Silibor” tablets. The results obtained suggest that it is possible to extend the range of available hepatoprotectors and improve the quality of treatment for liver diseases, by introducing “Phytovenol” capsules into medical practice.

Keywords

EN

liver; hepatitis; “Phytovenol” capsules; hepatoprotective action

• Publisher: De Gruyter Open
• Journal: Current Issues in Pharmacy and Medical Sciences
• Year: 2014
• Volume: 27
• Issue: 4
• Pages: 240-242

Dates

published

1 - 12 - 2014

accepted

12 - 12 - 2014

online

3 - 3 - 2015

received

7 - 11 - 2014

Contributors

author

Oleg Gerush

• Bukovinian State Medical University, Department of Pharmacy, Department of Bio-organic and Biological Chemistry and Clinical Biochemistry, 2 Teatralna Sq., Chernivtsi, Ukraine

author

Olena Lenytska

• National Pharmaceutical University, Department of Pharmacoeconomics, Central Scientific-Research Laboratory, Kharkiv, Ukraine

author

Larysa Yakovleva

• National Pharmaceutical University, Department of Pharmacoeconomics, Central Scientific-Research Laboratory, Kharkiv, Ukraine

author

Liudmyla Gladkova

• National Pharmaceutical University, Department of Pharmacoeconomics, Central Scientific-Research Laboratory, Kharkiv, Ukraine

author

Igor Gerush

• Bukovinian State Medical University, Department of Pharmacy, Department of Bio-organic and Biological Chemistry and Clinical Biochemistry, 2 Teatralna Sq., Chernivtsi, Ukraine

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Identifiers

DOI

10.1515/cipms-2015-0024