"Imageable" Zinc-Silicate Glass Microspheres For
Transarterial Embolization: A Renal Artery
Embolization Study.

• Authors: Sharon Kehoe , Salma Amensag , Mark Looney , Robert J. Abraham , Daniel Boyd
• Languages of publication: EN

Abstracts

EN

Intrinsically radiopaque (imageable) microspheres
for transarterial embolization (TAE) are required
to enable real-time intraprocedural feedback and definition
of spatial distribution patterns of embolic materials
in target tissues. This pilot study evaluates acute and
sub-chronic safety and efficacy of imageable zinc-silicate
(Zn-Si) glass microspheres in a swine renal artery embolization
(RAE) model. Eight swine were divided into
two cohorts. Clinical determinants of embolization effectiveness,
including imageability, deliverability and temporal/
spatial distribution of microspheres in target tissues
were assessed. Subsequently, cohort I and II were used to
evaluate the acute and subchronic host response against
the Zn-Si microspheres versus a clinical control. The developed
microspheres provide for direct intraprocedural
feedback using standard diagnostic imaging techniques.
Fluoroscopy correlated with ex-vivo high-resolution radiography,
CT and micro-CT, demonstrating high imageability,
excellent spatial distribution and packing of the Zn-
Si microspheres. At follow-up, infarction of the embolized
kidneys was noted without any major adverse tissue reaction.
Mild recanalization was observed microscopically
for both experimental and control microspheres. Zn-Si microspheres
permit the definition of spatial distribution in
a target tissue, consequently permitting the optimization,
personalization and improvement of TAE techniques.

Keywords

EN

Zinc-Silicate Glass; Embolic Microspheres; Radiopacity; Embolization; Swine Renal Artery Embolization; Biocompatibility

• Publisher: De Gruyter Open
• Journal: Biomedical glasses
• Year: 2015
• Volume: 1
• Issue: 1

Dates

online

26 - 8 - 2015

received

8 - 6 - 2015

accepted

8 - 6 - 2015

Contributors

author

Sharon Kehoe

author

Salma Amensag

author

Mark Looney

author

Robert J. Abraham

author

Daniel Boyd

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Identifiers

DOI

10.1515/bglass-2015-0007