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Background: Social attitudes and context have a fundamental impact on the COVID-19 vaccine acceptance. This issue will be challenging the existing Polish public health infrastructure during the planned immunisation program. Material and methods: We attempt to exemplify Poland-specific social background via causal diagram and regional factor analysis based on dimensions (epidemiological potential, ability to act, magical thinking, koronascepticism, information needs etc.) by December 2020 – shortly before vaccination started. Results: We identified several potential target subpopulations and provide possible regional classification. We distinguish clusters of regions where communication strategies should be taken into consideration: 1) extending campaign reach, common social goods and conformism; 2) individual’s profits and misinformation blocking. Conclusions: We are signalling the need for profiling and regionalization in campaigns and propose possible starting points for protocols for various voivodeships when safe and effective vaccines are available in Poland.
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