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Laryngeal sarcoidoisis – a case report

100%
Michałkowska-Pędzisz M., Raczkowska-Łabuda K., Dobrzyński P.
Polski Przegląd Otorynolaryngologiczny
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2019
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vol. 8(2)
38-42
EN
Introduction: Sarcoidosis is a multi-organ disease characterized by noncaseating granulomas. The lesions are usually localized within the lungs and hilar lymph nodes. The sarcoidosis of the upper respiratory tract (SURT) rate is estimated at 0.5–6%. The involvement of the larynx is extremely rare – it occurs in 1.2% of cases of SURT. Materials and methods. We present a case of a patient with laryngeal sarcoidosis. Results: A 48-year-old man had had a diagnosed of dysphonia for 5 years. A diagnosis of chronic hypertrophic laryngitis was made. Empirical course of methylprednisolone was attempted with a short-term improvement. Due to coexisting skin lesions, he was diagnosed with allergy. Chest CT showed moderately enlarged mediastinal and hilar lymph nodes as well as bilateral nodules around the hila. The bronchial biopsy showed no granulomas. Samples taken during microlaryngoscopy revealed sarcoid infiltrates. Conclusions and discussion: There is no unambiguous test confirming the diagnosis of sarcoidosis. It is a typical example of a diagnosis by exclusion. Laryngeal involvement is extremely rare and occurs in 1.2% of cases of SURT. The clinical course of the disease is often difficult to predict. In many patients, the lesion may undergo spontaneous regression. In patients poorly responding to steroid therapy or developing side effects, cytotoxic drugs may be considered.
2
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Differentiation by random amplified polymorphic DNA-polymerase chain reaction (RAPD-PCR) of Candida albicans isolated from upper respiratory tract in patients with non-small cell lung cancer

100%
Biernasiuk A., Korona-Głowniak I., Grzegorczyk A., Malm A.
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2014
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vol. 61
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issue 4
727-729
EN
Cancer patients are predisposed to fungal infections caused by Candida albicans, especially to oral or respiratory tract candidiasis. The aim of this study was to estimate genetic diversity by RAPD-PCR (random amplified polymorphic DNA-polymerase chain reaction) of C. albicans isolated from upper respiratory tract of 100 patients with non-small cell lung cancer. Among 52 strains, 34 genotypes were defined. 10 clusters comprising 28 (53.85%) isolates with similarity coefficient ≥ 80% were formed. The remaining 24 (46.15%) isolates represented individual genotypes. The RAPD-PCR technique revealed genomic variability within C. albicans isolated from upper respiratory tract of the cancer patients.
3
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Diagnostic difficulties with COVID-19 in a patient after total laryngectomy

88%
Czech J., Burduk P., Wierzchowska M.
Polski Przegląd Otorynolaryngologiczny
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2021
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vol. 10(2)
44-47
EN
Coronavirus disease (COVID-19) is caused by the SARS-CoV-2 virus and often presents with flu-like symptoms that can have varying degrees, which may subsequently lead to acute respiratory distress (ARDS). The genetic material of the virus in samples of respiratory secretions is identified by way of basic diagnostic tests. Due to the altered course of the respiratory tract, patients after total laryngectomy require special attention in the diagnosis of SARS-CoV-2 infection. We present a case of a patient after laryngectomy who obtained different results of COVID-19 tests depending on the site of sampling.
4
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Czynniki ryzyka związane ze stylem i jakością życia a częstość zachorowań na nowotwory złośliwe górnych dróg oddechowych w mikroregionie Mysłowice, Imielin i Chełm Śląski

75%
Stockfisch J., Markowski J., Pilch J., Zemła B., Dziubdziela W., Likus W., Bajor G.
Annales Academiae Medicae Silesiensis
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2014
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vol. 68
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issue 1
38-46
EN
INTRODUCTION The most frequent risk factors of malignant neoplasms in the upper respiratory tract (MNURT) are tobacco smoking, excessive consumption of spirits with a high percentage of alcohol, vitamin A deficiency, genetic pre-disposition, as well as exposure to carcinogenic compounds present in the environment. The aim of the study was to analyze the life style and quality of life factors, and their influence upon the incidence of MNURT within the micro-region of Mysłowice. MATERIAL AND METHODS The paper presents a retrospective analysis of MNURT incidence in the towns of Mysłowice, Imielin, and Chełm Śląski, on the basis of materials concerning patients treated in the Laryngologic Ward of the Mysłowice hospital, in the years 1995–2004. On the basis of patients’ data, the authors carried out analysis of MNURT incidence in correlation with risk factors related to the work in which patients were engaged, the number of cigarettes smoked as function of time, consumption of strong alcohols, social and living conditions, place of employment, current place of residence, as well as education. RESULTS Cigarette smoking and/or consumption of strong alcohols are the main risk factors in MNURT. The level of education as well as socio-economic status are also significant risk factors in MNURT incidence. CONCLUSIONS The firm conclusion of the paper is that the increased number of cases of MNURT in the micro-region of Mysłowice, Imielin, and Chełm Śląski may be due to the living conditions, higher level of consumption of strong alcohols, excessive cigarette smoking, as well as low socio-economic status of the examined patients.
PL
WSTĘP Najczęściej wymienianymi czynnikami ryzyka w nowotworach złośliwych górnych dróg oddechowych (NZGDO) jest palenie tytoniu, nadmierne spożycie wysokoprocentowego alkoholu, niedobór witaminy A, predyspozycja genetyczna i narażenie na działanie związków rakotwórczych pochodzenia środowiskowego. Celem pracy była analiza czynników związanych ze stylem i jakością życia oraz ich wpływ na zachorowalność na NZGDO w obrębie mikroregionu Mysłowic. MATERIAŁ I METODY W pracy przedstawiono retrospektywną analizę zachorowań na NZGDO w obrębie miejscowości: Mysłowice, Imielin i Chełm Śląski na podstawie danych oddziału laryngologicznego szpitala w Mysłowicach z lat 1995–2004. Dokonano analizy zapadalności na NZGDO w korelacji z czynnikami ryzyka związanymi z wykonywaną pracą, liczbą wypalanych papierosów, czasem palenia, spożyciem wysokoprocentowego alkoholu, warunkami socjalno-bytowymi, miejscem zatrudnienia i aktualnym miejscem zamieszkania, chorobami współistniejącymi i poziomem wykształcenia. WYNIKI Z analizy wynika, że głównymi czynnikami ryzyka w NZGDO były palenie papierosów i/lub spożywanie wysokoprocentowego alkoholu. Liczba i rodzaj wypalanych papierosów wiąże się istotnie ze wzrostem zapadalności na NZGDO. Znaczącymi czynnikami ryzyka są także poziom wykształcenia i status społeczno-ekonomiczny: im wyższy poziom wykształcenia, tym mniejsze ryzyko zachorowania. WNIOSKI Zwiększona liczba zachorowań na NZGDO w mikroregionie Mysłowic, Imielina i Chełmu Śląskiego może wiązać się ze zwiększonym spożyciem wysokoprocentowych alkoholi, nadmierną liczbą wypalanych papierosów oraz niskim statusem społeczno-ekonomicznym badanych chorych. W pracy potwierdzono wpływ uznanych czynników ryzyka na częstość zachorowań na NZGDO.
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