The rapid civilisational development that took place in the second half of the 20th century, and the resulting changes in the conditions and ways of people’s lives brought forth a number of social phenomena, both positive and negative. Physical activities, i.e. any forms of physical effort undertaken voluntarily in leisure time for entertainment and health purposes, contribute greatly to overcoming the dangers of modern civilization. Among these, activities with the participation of a dog are becoming increasingly popular. These activities are exercised by people of all ages in the form of dog sports, as well as for recreational and therapeutic purposes. The aim of the paper is to present various forms of activities with a dog as modern types of physical recreation exercised by people of all ages. Regular exercise with a dog greatly improves the well-being and provides a feeling of harmony and inner peace. It is becoming yet another modern form of activity.
Type 1 diabetes is a metabolic disorder whose treatment depends not only on the administration of insulin and diabetic control,but also on properly applied physical activity to improve insulin sensitivity and thus the patient’s condition. In order to fulfill this role,physical exercise must be systematic and properly administered. An adequate intensity depends on the physical fitness level of thepatient, which may be determined in a six-minute walk test. Before a training cycle, the patient should be subjected to basic clinical tests. The intensity of training may be determined by the Karvonen or Strunz formula to precisely specify the training heart rate (60–75% of maximum heart rate, depending on the condition of the indivi dual). Blood sugar levels should be measured before and after the training session, while during exercise a heart rate monitor should be used. All these measures should help prevent the occurrence of adverse effects such as hypoglycemia.
Growth arrest and DNA damage-inducible (GADD) 45 proteins are regulators of cell death and survival. The proinflammatory cytokine IL-1β strongly increases the level of the transcript encoding GADD45α in rat insulin-producing INS-1E cells. The activation of Gadd45α gene is clearly dependent on JNK and NF-κB activation and the synthesis of the secondary mediator nitric oxide (NO). Interestingly, the observed twelve-fold increase in the GADD45α-coding transcript level is not followed by increased expression of GADD45α at the protein level. An analysis of IL-1β toxicity in INS-1E cells overexpressing GADD45α revealed no correlation between the GADD45α protein level and the sensitivity to IL-1β toxicity. These findings suggest that the potential engagement of GADD45α in IL-1β toxicity towards beta cells is limited to the effects induced by the basal expression level of this protein.
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.