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1,3-OXAZOLIDIN-5-ONES DERIVED FROM PROLINE AS CHIRAL COMPONENTS IN THE SYNTHESIS OF PREDICTIVE ENANTIOSELECTIVE COUPLING REAGENTS

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Kasperowicz-Frankowska K., Kolesińska B., Gzik A., Jastrząbek K., Kaminski Z. J.
Acta Poloniae Pharmaceutica - Drug Research
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2018
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vol. 75
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issue 4
921-927
EN
1,3-Oxazolidin-5-ones derived from both enantiomers of proline and trichloroacetaldehyde were prepared and applied as amine component in the synthesis of chiral predictive triazine based coupling reagents. The usefulness of these reagents in the condensations yielding enantiomerically enriched products from racemic substrates was presented.
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