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DEVELOPMENT OF HYDROGEL CAPSULES FOR USE IN DUAL-PHASE TOPICAL PREPARATIONS CONTAINING DIHYDROXYACETONE AND AMINO ACIDS – PRELIMINARY RESULTS

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Jacyna B., Mikolaszek B., Maciejewski B., Cal K.

Acta Poloniae Pharmaceutica - Drug Research

2019

vol. 76

issue 4

715-724

The aim of the following work was a preliminary assessment of the possibility of producing a topical preparation containing dihydroxyacetone (DHA) and amino acids, encapsulated separately in polysaccharide capsules. The colour reaction between the DHA and amino acids would be possible after mixing of the two components triggered with mechanical disruption of the capsules on application. Such preparation could be used in patients suffering from vitiligo, by masking the symptoms of the disease. Several capsule compositions were evaluated in terms of appearance, dimensions and mechanical parameters. In addition, the reactions of various amino acids with DHA were carried out and obtained colours were analysed. The results indicate that formation of the dual-phase formulation of encapsulated DHA and amino acids is possible. It was also found that certain amino acids vary in colour resulting from reaction with DHA. This feature can be potentially utilized to better design the colour resulting from application of the prepared composition.

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1 Acta Poloniae Pharmaceutica - Drug Research

1 2019

1 Cal K.

1 Jacyna B.

1 Maciejewski B.

1 Mikolaszek B.

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DEVELOPMENT OF HYDROGEL CAPSULES FOR USE IN DUAL-PHASE TOPICAL PREPARATIONS CONTAINING DIHYDROXYACETONE AND AMINO ACIDS – PRELIMINARY RESULTS